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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 464 - 470 (7page)
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All the parts of the Cedrela sinensis A. Juss., including the seeds, roots, and leaves, have been known to exert medicinal effects. The C. sinensis and its major compound, quercetin, were previously reported to exhibit the anti-inflammatory and anti-oxidative activities. However, the hepatoprotective effects of the C. sinensis leaves against the alcohol-induced oxidative stress in the HepG2 cells have not been studied. In this study, we investigated the antioxidant activities and analyzed the flavonoid contents of the C. sinensis-leaf extract (CE). The total flavonoid contents of the CE is 1,874.5 mg/100 g dry weight (DW), while the total quercetin 3-O-rhamnoside (quercitrin) contents, which was identified as the major flavonol in the CE, is 1,456.0 mg/100 g DW. In the ethanol-stimulated HepG2 cells, the CE effectively prevented the cytotoxic effect and increased the gene expression of the antioxidant enzymes, such as the heme oxygenase-1 (HO-1) and the glutathion peroxide (GPx). The level of the reactive oxygen species (ROS) production was significantly decreased in the CE-treated HepG2 cells. In conclusion, the C. sinensis extract suppressed the alcohol-induced oxidative stress in the HepG2 cells via the induced GPx and HO-1 gene expressions. It is expected the CE positive effects will likely be attributed to the flavonoids, like the quercetin, within the CE. Key words: Cedrela sinensis A. Juss., ethanol, hepatocyte, ROS, antioxidant
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참고문헌 (27)
참고문헌 신청
Albano E / 2006 / Alcohol, oxidative stress and free radical damage / Proc Nutr Soc 65:278~290
Bass DA / 1983 / Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation / J Immunol 130:1910~1917
Cederbaum AI / 1990 / Microsomal generation of reactive oxygen species and their possible role in alcohol hepatotoxicity / Alcohol and Alcoholism (Oxford, Oxfordshire) (Supplement 1):291~296
최창환 / 2012 / 골풀 부위별 추출물의 항산화 효과 / 대한화장품학회지 38(3):275~282
Chow JM / 2005 / Quercetin, but not rutin and quercitrin, prevention of $H_2O_2$ -induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages / Biochem Pharmacol 69:1839~1851
Bass DA / 1983 / Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation / J Immunol 130:1910~1917
Cederbaum AI / 1990 / Microsomal generation of reactive oxygen species and their possible role in alcohol hepatotoxicity / Alcohol and Alcoholism (Oxford, Oxfordshire) (Supplement 1):291~296
최창환 / 2012 / 골풀 부위별 추출물의 항산화 효과 / 대한화장품학회지 38(3):275~282
Chow JM / 2005 / Quercetin, but not rutin and quercitrin, prevention of
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