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논문 기본 정보
- 자료유형
- 학술저널
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- 2015.1
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Background: The demand for healthy, lean and consistent meat products containing low saturated fatty acidcontent and high quality polyunsaturated fatty acids (PUFA), especially long-chain (≥C20) omega-3 PUFA, hasincreased in recent times. Fat deposition is altered by both the genetic background and dietary supplements, andthis study aimed to assess the effect of dietary Spirulina supplementation levels on the mRNA expression patternsof genes controlling lipid metabolism in the subcutaneous adipose tissue (SAT) and Longissimus dorsi (ld) muscle ofAustralian crossbred sheep.
Methods: Twenty-four weaned lambs belonging to four breeds under the same management conditions weremaintained on ryegrass pasture and fed three levels of Spirulina supplement (control, low and high). In terms ofnutrient composition, Spirulina is a nutrient-rich supplement that contains all essential amino acids, vitamins andminerals. It also is a rich source of carotenoids and fatty acids, especially gamma-linolenic acid (GLA) that inferhealth benefits. After slaughter, subcutaneous adipose tissue (SAT) and ld samples were subjected to mRNAextraction and reverse transcription using quantitative polymerase chain reaction (RT-qPCR) to assess the mRNAexpression levels of the Aralkylamine N-acetyltransferase (AANAT), Adrenergic beta-3 receptor (ADRB3), B-celltranslocation gene 2 (BTG2) and Fatty acid synthase (FASN) genes, which are associated with lipid metabolism.
Results: Both low and high Spirulina supplementation levels strongly up-regulated the transcription of all theselected genes in both SAT and ld tissues (mostly in the subcutaneous adipose), but sheep breed and sex did notinfluence the gene expression patterns in these tissues.
Conclusions: The evidence indicates that high Spirulina supplementation level resulted in a decrease inintramuscular fat content in Australian purebred and crossbred sheep due to the enhanced production ofmelatonin in sheep muscle tissues and strong up-regulation of mRNA expression of BTG2 in SAT which negativelyaffected fat deposition. In contrast, low Spirulina supplementation level strongly up-regulated the ADRB3 and FASNgenes responsible for fat production. These findings are consistent with the observed phenotypic data suggestingthat low Spirulina supplementation level can increase lamb production, with higher long-chain PUFA content.
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참고문헌 (24)
참고문헌 신청
[학술지(정기
Berndt J / 2007 / Fatty acid synthase gene expression in human adipose tissue : association with obesity and type 2 diabetes / Diabetologia 50 : 1472 ~ 1480
Bichi E / 2013 / Dietary marine algae and its influence on tissue gene network expression during milk fat depression in dairy ewes / Anim Feed Sci Technol 186 : 36 ~ 44
Boizard M / 1998 / Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors / J B
Clement K / 1995 / Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity / N Engl J Med 333 : 352 ~ 354
Berndt J / 2007 / Fatty acid synthase gene expression in human adipose tissue : association with obesity and type 2 diabetes / Diabetologia 50 : 1472 ~ 1480
Bichi E / 2013 / Dietary marine algae and its influence on tissue gene network expression during milk fat depression in dairy ewes / Anim Feed Sci Technol 186 : 36 ~ 44
Boizard M / 1998 / Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors / J B
Clement K / 1995 / Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity / N Engl J Med 333 : 352 ~ 354
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