지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 587 - 594 (8page)
이용수
초록· 키워드
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Background/Aims: The roles of the many bioactive peptides in the pathogenesis of celiac disease remain unclear. To evaluate the serum concentrations of insulin, ghrelin, adiponectin, leptin, leptin receptor, and lipocalin-2 in children with celiac disease who do and do not adhere to a gluten-free diet (GFD, intermittent adherence). Methods: Prepubertal, pubertal, and adolescent celiac children were included in this study (74 girls and 53 boys on a GFD and 80 girls and 40 boys off of a GFD). Results: Insulin levels in prepubertal (9.01±4.43 μIU/mL), pubertal (10.3±3.62 μIU/mL), and adolescent (10.8±4.73 μIU/mL) girls were higher than those in boys (5.88±2.02, 8.81±2.88, and 8.81±2.26 μIU/mL, respectively) and were neither age-dependent nor influenced by a GFD. Prepubertal children off of a GFD exhibited higher ghrelin levels than prepubertal children on a GFD. Adiponectin levels were not age-, sex- nor GFD-dependent. Adherence to a GFD had no effect on the expression of leptin, leptin receptor, and lipocalin-2. Conclusions: Adherence to a GFD had no influence on the adiponectin, leptin, leptin receptor, and lipocalin-2 concentrations in celiac children, but a GFD decreased highly elevated ghrelin levels in prepubertal children. Further studies are required to determine whether increased insulin concentrations in girls with celiac disease is suggestive of an increased risk for hyperinsulinemia.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Green PH / 2007 / Celiac disease / N Engl J Med 357:1731~1743
Guandalini S / 2014 / Celiac disease: a review / JAMA Pediatr 168:272~278
Hill ID / 2005 / Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition / J Pediatr Gastroenterol Nutr 40:1~19
Husby S / 2012 / European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease / J Pediatr Gastroenterol Nutr 54:136~160
McGowan KE / 2009 / The changing face of childhood celiac disease in North America: impact of serological testing / Pediatrics 124:1572~1578
Guandalini S / 2014 / Celiac disease: a review / JAMA Pediatr 168:272~278
Hill ID / 2005 / Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition / J Pediatr Gastroenterol Nutr 40:1~19
Husby S / 2012 / European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease / J Pediatr Gastroenterol Nutr 54:136~160
McGowan KE / 2009 / The changing face of childhood celiac disease in North America: impact of serological testing / Pediatrics 124:1572~1578
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