지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제5호
- 발행연도
- 2021.9
- 수록면
- 492 - 499 (8page)
- DOI
- 10.5223/pghn.2021.24.5.492
이용수
초록· 키워드
오류제보하기
Purpose: Celiac disease (CD) is an autoimmune disorder of the small intestine caused by an abnormal immune response to gluten proteins and is often characterized by gastrointestinal symptoms. Food allergy (FA) is an adverse immune sensitivity to ingested food proteins leading to inflammation in various organs including the gastrointestinal tract. The relationship between CD and FA remains unclear. This study aimed to assess the prevalence and clinical relevance of immunoglobulin E (IgE)-mediated food sensitization in children with CD.
Methods: Fifty-nine children diagnosed with CD were reviewed for clinical symptoms and evidence of IgE-sensitization to food and airborne allergens using the PolyCheck method.
Results: IgE-mediated sensitization has been diagnosed in 20.3% of children with CD (CD/ A). In the CD/A group, 58.3% of children were sensitized to food and 66.7% to airborne allergens. Further, 41.7% of patients with CD and allergy reported gastrointestinal tract symptoms associated with the ingestion of sensitizing foods. Analysis of the clinical status revealed that the incidence of other allergic disorders in the CD/A group was as follows: atopic dermatitis (33.3%), asthma (25.0%), and allergic rhinitis (16.7%). The percentage of eosinophils was significantly higher in the CD/A group than in the CD group (0.33±0.25 vs.
0.11±0.09; p=0.006).
Conclusion: The diagnosis of CD does not exclude FA. The gastrointestinal symptoms in children with CD may be the result of both CD and FA; therefore, children with CD should be evaluated for the presence of FA regardless of age.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Kårhus LL / 2019 / The association of celiac disease and allergic disease in a general adult population / United European Gastroenterol J 7:78~89
Ciacci C / 2004 / Allergy prevalence in adult celiac disease / J Allergy Clin Immunol 113:1199~1203
Lebwohl B / 2018 / Coeliac disease / Lancet 391:70~81
Peyman H / 2011 / Food allergy in patients with confirmed celiac disease / Clin Transl Allergy 1(Suppl 1):P27
Bischoff SC / 2000 / Allergy and the gut / Int Arch Allergy Immunol 121:270~283
Ciacci C / 2004 / Allergy prevalence in adult celiac disease / J Allergy Clin Immunol 113:1199~1203
Lebwohl B / 2018 / Coeliac disease / Lancet 391:70~81
Peyman H / 2011 / Food allergy in patients with confirmed celiac disease / Clin Transl Allergy 1(Suppl 1):P27
Bischoff SC / 2000 / Allergy and the gut / Int Arch Allergy Immunol 121:270~283
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