지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 379 - 384 (6page)
이용수
초록· 키워드
오류제보하기
Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatment upregulated the expression of HIF1, but reduced TP53I11 protein levels and TP53I11 overexpression reduced HIF1 expression under normal culture and hypoxicconditions, and in xenografts of MDA-MB-231 cells. Considering HIF1 is a master regulator of the hypoxic response and that hypoxia is a crucial trigger of cancer metastasis, our study suggests that TP53I11 may suppress EMT and metastasis by reducing HIF1 protein levels in breast cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Yilmaz M / 2009 / EMT, the cytoskeleton, and cancer cell invasion / Cancer Metastasis Rev 28:15~33
Valastyan S / 2011 / Tumor metastasis : molecular insights and evolving paradigms / Cell 147:275~292
Zhou Y / 2018 / Nuclear respiratory factor 1 promotes spheroid survival and mesenchymal transition in mammary epithelial cells / Oncogene 37:6152~6165
Au SH / 2016 / Clusters of circulating tumor cells traverse capillary-sized vessels / Proc Natl Acad Sci U S A 113:4947~4952
Grimshaw MJ / 2008 / Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells / Breast Cancer Res 10:R52
Valastyan S / 2011 / Tumor metastasis : molecular insights and evolving paradigms / Cell 147:275~292
Zhou Y / 2018 / Nuclear respiratory factor 1 promotes spheroid survival and mesenchymal transition in mammary epithelial cells / Oncogene 37:6152~6165
Au SH / 2016 / Clusters of circulating tumor cells traverse capillary-sized vessels / Proc Natl Acad Sci U S A 113:4947~4952
Grimshaw MJ / 2008 / Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells / Breast Cancer Res 10:R52
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation of HIF-1α stability by lysine methylation
BMB Reports
2016 .01
-
Determination of HIF-1α degradation pathways via modulation of the propionyl mark
BMB Reports
2023 .04
-
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Experimental and Molecular Medicine
2024 .03
-
Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity
Experimental and Molecular Medicine
2015 .01
-
Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Experimental and Molecular Medicine
2022 .11
-
High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Experimental and Molecular Medicine
2017 .01
-
Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss
Experimental and Molecular Medicine
2021 .04
-
Hypoxia signaling in human diseases and therapeutic targets
Experimental and Molecular Medicine
2019 .01
-
Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition
Experimental and Molecular Medicine
2019 .01
-
Suppression of Akt-HIF-1α signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
BMB Reports
2016 .01
-
Fibroblast Spheroids Induce the Epithelial-mesenchymal Transition of Breast Epithelial Cells in a Paracrine Manner
한국정밀공학회 학술발표대회 논문집
2021 .11
-
MicroRNAs: promising biomarkers for diagnosis and therapeutic targets in human colorectal cancer metastasis
BMB Reports
2015 .01
-
TPS 기반의 직류 급전 시뮬레이션 시스템 개발
대한전기학회 학술대회 논문집
2019 .07
-
RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma
Experimental and Molecular Medicine
2016 .01
-
Emerging paradigms in cancer cell plasticity
BMB Reports
2024 .06
-
돌연변이 p53 단백질의 Silencing에 의한 사람유방암세포의 in vivo 항종양 효과
KSBB Journal
2016 .03
-
Unity Engine을 이용한 3D TPS 게임 구현
Proceedings of KIIT Conference
2016 .06
-
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Experimental and Molecular Medicine
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0