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논문 기본 정보

자료유형
학술저널
저자정보
Kim Moonsik (Department of Pathology School of Medicine Kyungpook National University Kyungpook National Univers) Seo An Na (Department of Pathology School of Medicine Kyungpook National University Kyungpook National Univers)
저널정보
대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제22권 제4호
발행연도
2022.10
수록면
273 - 305 (33page)
DOI
10.5230/jgc.2022.22.e35

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초록· 키워드

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Gastric cancer (GC) is one of the most common lethal malignant neoplasms worldwide, with limited treatment options for both locally advanced and/or metastatic conditions, resulting in a dismal prognosis. Although the widely used morphological classifications may be helpful for endoscopic or surgical treatment choices, they are still insufficient to guide precise and/or personalized therapy for individual patients. Recent advances in genomic technology and high-throughput analysis may improve the understanding of molecular pathways associated with GC pathogenesis and aid in the classification of GC at the molecular level. Advances in next-generation sequencing have enabled the identification of several genetic alterations through single experiments. Thus, understanding the driver alterations involved in gastric carcinogenesis has become increasingly important because it can aid in the discovery of potential biomarkers and therapeutic targets. In this article, we review the molecular classifications of GC, focusing on The Cancer Genome Atlas (TCGA) classification. We further describe the currently available biomarker-targeted therapies and potential biomarker-guided therapies. This review will help clinicians by providing an inclusive understanding of the molecular pathology of GC and may assist in selecting the best treatment approaches for patients with GC.

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