지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 210 - 217 (8page)
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BackgroundDiscrepancies in the results between hepatitis B e-antigen (HBeAg) and hepatitis B virus (HBV) DNA levels pose difficulties in the management of chronic hepatitis B (CHB). This study aims to better understand the different phases of CHB and to detect additional meaningful parameters for CHB patients. MethodsWe collected datasets of HBeAg and HBV DNA levels measured during 2016 and the follow-up results for CHB patients for past 3 years. We analyzed the collected data by applying the definitions of CHB clinical phase and compared the results of semi-quantitative and quantitative HBeAg assays. ResultsAbout 55% of 2,291 result pairs from CHB patients showed qualitative agreement between HBeAg and HBV DNA results. HBeAg (−) CHB was reported in 16.49%, while hepatitis B surface antigen (HBsAg) loss occurred in 0.18% among 1,146 patients annually. HBeAg reversion occurred in 2.74% of 839 patients that experienced HBeAg seroconversion. Patients with HBeAg (+) and HBV DNA (−) showed statistically significant differences in the levels and percentage abnormality of alanine aminotransferase (ALT) based on whether HBV DNA was ‘Target not detected’ or ‘Detected, <LOQ’. A strong correlation (r2=0.9435) was observed between semi-quantitative and quantitative HBeAg assay results. ConclusionsThis study reveals clinically important result patterns during the different phases of CHB. ALT level and percentage abnormality were significantly different based on HBV DNA status in HBeAg (+) and HBV DNA (−) patients. We suggest that clinical laboratories should report ‘HBV DNA (−)’ separately as ‘Target not detected’ and ‘Detected, <LOQ’.
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참고문헌 (22)
참고문헌 신청
World Health Organization / Hepatitis B
Hasan KN / 2002 / Chronic carriers of hepatitis B virus in Bangladesh : a comparative analysis of HBV-DNA, HBeAg/anti-HBe, and liver function tests / Southeast Asian J Trop Med Public Health 33:110~117
Chen P / 2017 / Serum HBeAg and HBV DNA levels are not always proportional and only high levels of HBeAg most likely correlate with high levels of HBV DNA: A community-based study / Medicine (Baltimore) 96:e7766
da Silva LC / 2009 / Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B / Rev Inst Med Trop Sao Paulo 51:261~268
Lee KS / 2016 / KASL clinical practice guidelines : management of chronic hepatitis B / Clin Mol Hepatol 22:18~75
Hasan KN / 2002 / Chronic carriers of hepatitis B virus in Bangladesh : a comparative analysis of HBV-DNA, HBeAg/anti-HBe, and liver function tests / Southeast Asian J Trop Med Public Health 33:110~117
Chen P / 2017 / Serum HBeAg and HBV DNA levels are not always proportional and only high levels of HBeAg most likely correlate with high levels of HBV DNA: A community-based study / Medicine (Baltimore) 96:e7766
da Silva LC / 2009 / Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B / Rev Inst Med Trop Sao Paulo 51:261~268
Lee KS / 2016 / KASL clinical practice guidelines : management of chronic hepatitis B / Clin Mol Hepatol 22:18~75
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