지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Veno-occlusive disease (VOD) is a potentially devastating complication that can develop after hematopoietic stem cell transplantation (HSCT). The incidence is higher for allogeneic than autologous HSCT. Previous studies on the prevention of VOD with pentoxifylline have limitations to apply for the present state due to the difference of VOD criteria. This study examines the effectiveness of pentoxifylline in preventing VOD according to current diagnostic criteria for a patient with allogeneic HSCT. Methods : Allogeneic HSCT recipients from 2013 to 2018 were selected for this retrospective analysis. Subjects were divided into three groups depending on pentoxifylline administration. The first and the second group took pentoxifylline for more than two weeks and for less than two weeks respectively, while the last group did not take it. The primary endpoints were the incidence rates of VOD. Secondary endpoints were hyperbilirubinemia (≥2 mg/dL), weight gain ( 5% of baseline), painful hepatomegaly, ascites, and taking VOD treatment (defibrotide) or liver function agent. Results : 210 patients were included. The incidence rate of VOD was 5.0% in the first group vs. 6.5% in the second group vs. 6.5% in the last group (p=0.779). There was no significantly difference in hyperbilirubinemia (p=0.844), weight gain (p=0.292), painful hepatomegaly (p=0.093), ascites (p=0.912), taking defibrotide (p=0.886), taking liver function agent (p=0.508). Conclusions : This study confirmed that there is no VOD prevention effect of pentoxifylline in patients with allogeneic HSCT. Further studies are needed to develop more effectiveness prophylactic approaches of VOD.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Mohty M / 2016 / Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/venoocclusive disease in adult patients : a new classification from the European Society for Blood and Marrow Transplantation / Bone Marrow Transplant 51(7):906~912
Holler E / 1990 / Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation / Blood 75(4):1011~1016
Bianco JA / 1991 / Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation / Blood 78(5):1205~1211
Tilg H / 1993 / Immune response modulation by pentoxifylline in vitro / Transplantation 56(1):196~201
Strieter RM / 1988 / Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline / Biochem Biophys Res Commun 155(3):1230~1236
Holler E / 1990 / Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation / Blood 75(4):1011~1016
Bianco JA / 1991 / Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation / Blood 78(5):1205~1211
Tilg H / 1993 / Immune response modulation by pentoxifylline in vitro / Transplantation 56(1):196~201
Strieter RM / 1988 / Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline / Biochem Biophys Res Commun 155(3):1230~1236
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