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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제3호
- 발행연도
- 2019.1
- 수록면
- 388 - 399 (12page)
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초록· 키워드
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Objective: Hypoxic-ischemic (HI) brain injury in the human perinatal period often leads to significant long-term neurobehavioral dysfunction in the cognitive and sensory-motor domains. Using a neonatal HI injury model (unilateral carotid ligation followed by hypoxia) in postnatal day seven rats, the present study investigated the long-term effects of HI and potential behavioral protective effect of pentoxifylline. Methods: Seven-day-old rats underwent right carotid ligation, followed by hypoxia (FiO2 = 0.08). Rats received pentoxifylline immediately after and again 2 hours after hypoxia (two doses, 60‒100 mg/kg/dose), or serum physiologic. Another set of seven-day-old rats was included to sham group exposed to surgical stress but not ligated. These rats were tested for spatial learning and memory on the simple place task in the Morris water maze from postnatal days 77 to 85. Results: HI rats displayed significant tissue loss in the right hippocampus, as well as severe spatial memory deficits. Low-dose treatment with pentoxifylline resulted in significant protection against both HI-induced hippocampus tissue losses and spatial memory impairments. Beneficial effects are, however, negated if pentoxifylline is administered at high dose. Conclusion: These findings indicate that unilateral HI brain injury in a neonatal rodent model is associated with cognitive deficits, and that low dose pentoxifylline treatment is protective against spatial memory impairment
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등록된 정보가 없습니다.
참고문헌 (94)
참고문헌 신청
Trollmann R / 2009 / The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain / Brain Dev 31:503~509
Delsing BJ / 2001 / Early prognostic indicators of outcome in ischemic childhood stroke / Pediatr Neurol 24:283~289
Koelfen W / 1995 / Neonatal stroke involving the middle cerebral artery in term infants : clinical presentation, EEG and imaging studies, and outcome / Dev Med Child Neurol 37:204~212
Levine S / 1960 / Anoxic-ischemic encephalopathy in rats / Am J Pathol 36:1~17
Rice JE 3rd / 1981 / The influence of immaturity on hypoxic-ischemic brain damage in the rat / Ann Neurol 9:131~141
Delsing BJ / 2001 / Early prognostic indicators of outcome in ischemic childhood stroke / Pediatr Neurol 24:283~289
Koelfen W / 1995 / Neonatal stroke involving the middle cerebral artery in term infants : clinical presentation, EEG and imaging studies, and outcome / Dev Med Child Neurol 37:204~212
Levine S / 1960 / Anoxic-ischemic encephalopathy in rats / Am J Pathol 36:1~17
Rice JE 3rd / 1981 / The influence of immaturity on hypoxic-ischemic brain damage in the rat / Ann Neurol 9:131~141
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