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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제4호
- 발행연도
- 2019.1
- 수록면
- 251 - 261 (11page)
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초록· 키워드
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Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cellsderived cytokines are critically associated with asthma pathogenesis. Janus kinasesignal transduction and activation of transcription (JAK/STAT) signaling is found to be involved in asthma. Magnolol is a plant-derived bioactive compound with several pharmacological effects. The study aimed to assess the effects of magnolol in ovalbumin (OVA)-induced asthmatic model. BALB/c mice were sensitized and challenged with OVA. Magnolol (12.5, 25, or 50 mg/kg body weight) was administered to separate groups of animals. Dexamethasone was used as the positive control. Cellular infiltration into the bronchoalveolar lavage fluid (BALF) were reduced on magnolol treatment. The levels of Th2 and Th17 cytokines were reduced with noticeably raised levels of interferon gamma. Lung function was improved effectively along with restoration of bronchial tissue architecture. OVA-specific immunoglobulin E levels in serum and BALF were decreased by magnolol. Magnolol reduced Th17 cell population and effectively modulated the JAK-STAT and Notch 1 signaling. The results suggest the promising use of magnolol in therapy for allergic asthma.
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참고문헌 (72)
참고문헌 신청
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Bosnjak B / 2011 / Treatment of allergic asthma : modulation of Th2 cells and their responses / Respir Res 12:114
Galli SJ / 2008 / The development of allergic inflammation / Nature 454:445~454
김명신 / 2013 / Effects of Interleukin-9 Blockade on Chronic Airway Inflammation in Murine Asthma Models / Allergy, Asthma & Immunology Research 5(4):197~206
Wegmann M / 2009 / Th2 cells as targets for therapeutic intervention in allergic bronchial asthma / Expert Rev Mol Diagn 9:85~100
Bosnjak B / 2011 / Treatment of allergic asthma : modulation of Th2 cells and their responses / Respir Res 12:114
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