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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 481 - 491 (11page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.481
이용수
초록· 키워드
오류제보하기
Allergic asthma is one of the most enduring diseases of the airway. The T-helper cells and regulatory T-cells are critically involved in inflammatory responses, mucus hypersecretion, airway remodelling and in airway hyper-responsiveness.
Cigarette smoke (CS) has been found to aggravate inflammatory responses in asthma.
Though currently employed drugs are effective, associated side effects demand identification and development of novel drugs with negligible or no adverse effects.
Rutin, plant-derived flavonoid has been found to possess antioxidant and anti-inflammatory effects. We investigated the ability of rutin to modulate T-cells and inhibit inflammation in experimentally-induced asthma in cigarette smoke exposed mice.
Separate groups of neonatal mice were exposed to CS for 10 days from post-natal days 2 to 11. After 2 weeks, the mice were sensitized and challenged with ovalbumin (OVA). Treatment group were given rutin (37.5 or 75 mg/kg body weight) during OVA sensitization and challenge. Rutin treatment was found to significantly inhibit cellular infiltration in the airways and Th2 and Th17 cytokine levels as well. Flow cytometry revealed effectively raised CD4+CD25+Fox3+ Treg cells and supressed Th17 cell population on rutin treatment. Airway hyper-responsiveness observed following CS and OVA challenge were inhibited by rutin. NF-kB and iNOS, chief regulators of inflammatory responses robustly activated by CS and OVA were down-regulated by rutin. Rutin also inhibited the expression of matrix metalloproteinase 9, thereby aiding in prevention of airway remodelling in asthma thereby revealing to be a potent candidate in asthma therapy.
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참고문헌 (51)
참고문헌 신청
Galli SJ / 2008 / The development of allergic inflammation / Nature 454:445~454
Medoff BD / 2008 / T cell trafficking in allergic asthma: the ins and outs / Annu Rev Immunol 26:205~232
Bosnjak B / 2011 / Treatment of allergic asthma: modulation of Th2 cells and their responses / Respir Res 12:114
Hiroshi Nakajima / 2010 / Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma / Immune Network 10(1):1~4
Brewer JM / 1999 / Aluminium hydroxide adjuvant initiates strong antigenspecific Th2 responses in the absence of IL-4- or IL-13-mediated signaling / J Immunol 163:6448~6454
Medoff BD / 2008 / T cell trafficking in allergic asthma: the ins and outs / Annu Rev Immunol 26:205~232
Bosnjak B / 2011 / Treatment of allergic asthma: modulation of Th2 cells and their responses / Respir Res 12:114
Hiroshi Nakajima / 2010 / Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma / Immune Network 10(1):1~4
Brewer JM / 1999 / Aluminium hydroxide adjuvant initiates strong antigenspecific Th2 responses in the absence of IL-4- or IL-13-mediated signaling / J Immunol 163:6448~6454
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