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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.1
- 발행연도
- 2015.1
- 수록면
- 76 - 82 (7page)
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초록· 키워드
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Purpose: Extensive data support the influence of the upper airway on lower airway inflammation and pathophysiology in allergic disease. However, few studies have focused on allergic inflammation in the nose after an isolated lower airway allergen challenge, a situation that can exist clinically when human subjects breathe primarily through the mouth, as occurs when nasally congested. This study used a mouse model to investigate whether upper airway inflammation and hyperresponsiveness were induced by an isolated lower airway allergen challenge. Methods: BALB/c mice were sensitized by systemic intraperitoneal injection of ovalbumin/saline and challenged with intratracheal ovalbumin/saline. Inflammation in the nose and lungs was assessed by cytology and histology of nasal tissues and bronchoalveolar lavage fluid (BALF), while nasal airway resistance and response were measured over 3 days post-challenge. Results: Intratracheal application of an allergen in anaesthetized mice resulted in exclusive deposition in the lower airway. Compared to control animals, ovalbumin -sensitized mice after challenge showed bronchial hyperreactivity and increased IL-5 in the serum BALF, as well as eosinophil infiltration in the lungs. However, nasal histology of the ovalbumin-sensitized mice showed no increase in eosinophil infiltration. The nasal lavage fluid revealed no increase in eosinophils or IL-5, and the nasal airway resistance did not increase after challenge either. Conclusions: In a mouse allergy model, exclusive allergen challenge of the lower airway can elicit a pulmonary and systemic allergic response, but does not induce upper airway inflammatory or physiological responses.
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참고문헌 (28)
참고문헌 신청
Pawankar R / 2007 / Revisiting the link between allergic rhinitis and asthma / Curr Allergy Asthma Rep 7:77~78
Fasano MB / 2010 / Combined airways: impact of upper airway on lower airway / Curr Opin Otolaryngol Head Neck Surg 18:15~20
Krouse JH / 2007 / Asthma and the unified airway / Otolaryngol Head Neck Surg 136:S75~106
Leynaert B / 2004 / Association between asthma and rhinitis according to atopic sensitization in a population-based study / J Allergy Clin Immunol 113:86~93
Brown JL / 2007 / Lower airways inflammation in allergic rhinitics: a comparison with asthmatics and normal controls / Clin Exp Allergy 37:688~695
Fasano MB / 2010 / Combined airways: impact of upper airway on lower airway / Curr Opin Otolaryngol Head Neck Surg 18:15~20
Krouse JH / 2007 / Asthma and the unified airway / Otolaryngol Head Neck Surg 136:S75~106
Leynaert B / 2004 / Association between asthma and rhinitis according to atopic sensitization in a population-based study / J Allergy Clin Immunol 113:86~93
Brown JL / 2007 / Lower airways inflammation in allergic rhinitics: a comparison with asthmatics and normal controls / Clin Exp Allergy 37:688~695
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