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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 410 - 417 (8page)
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Estimation of postmortem interval (PMI) is a key issue in the field of forensic pathology. With the availability of quantitative analysis of RNA levels in postmortem tissues, several studies have assessed the postmortem degradation of constitutively expressed RNA species to estimate PMI. However, conventional RNA quantification as well as biochemical and physiological changes employed thus far have limitations related to standardization or normalization. The present study focus-es on an interesting feature of the subdomains of certain RNA species, in which they are site-specifically cleaved during apoptotic cell death. We found that the D8 divergent domain of ribosomal RNA (rRNA) bearing cell death-related cleavage sites was rapidly removed during postmortem RNA degradation. In contrast to the fragile domain, the 5' terminal region of 28S rRNA was remarkably stable during the postmortem period. Importantly, the differences in the degradation rates between the two domains in mammalian 28S rRNA were highly proportional to increasing PMI with a significant linear correlation observed in mice as well as human autopsy tissues. In conclusion, we demonstrate that comparison of the degradation rates between domains of a single RNA species provides quantitative information on postmortem degradation states, which can be applied for the estimation of PMI.
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참고문헌 (34)
참고문헌 신청
Bahar, B. / 2007 / Long-term stability of RNA in post-mortem bovine skeletal muscle, liver and subcutaneous adipose tissues / BMC Mol. Biol 8:108~120
Bauer, M. / 2007 / RNA in forensic science / Forensic Sci. Int. Genet 1:69~74
Bauer, M. / 2003 / Quantification of mRNA degradation as possible indicator of postmortem interval-a pilot study / Leg. Med 5:220~227
Brennan-Laun, S. E. / 2014 / RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting / J. Interferon Cytokine Res 34:275~288
정욱희 / 2012 / Quantitative Analyses of Postmortem Heat Shock Protein mRNA Profiles in the Occipital Lobes of Human Cerebral Cortices: Implications in Cause of Death / Molecules and Cells 34(5):473~480
Bauer, M. / 2007 / RNA in forensic science / Forensic Sci. Int. Genet 1:69~74
Bauer, M. / 2003 / Quantification of mRNA degradation as possible indicator of postmortem interval-a pilot study / Leg. Med 5:220~227
Brennan-Laun, S. E. / 2014 / RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting / J. Interferon Cytokine Res 34:275~288
정욱희 / 2012 / Quantitative Analyses of Postmortem Heat Shock Protein mRNA Profiles in the Occipital Lobes of Human Cerebral Cortices: Implications in Cause of Death / Molecules and Cells 34(5):473~480
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