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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 280 - 284 (5page)
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초록· 키워드
오류제보하기
Rhabdomyoma is the most common fetal cardiac tumor, and its development is related to tuberous sclerosis. Fetalcardiac rhabdomyomas often spontaneously regress in utero or after birth, but large tumors can cause hemodynamicobstruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used as an immunosuppressantafter organ transplantation. The mTOR inhibitors are well-known to have anti-tumor activity, and they have beenused for the treatment of patients with tuberous sclerosis. In the current case, fetal cardiac rhabdomyoma wascompletely resolved in utero during oral sirolimus treatment in the mother with tuberous sclerosis. This case showsthat oral sirolimus therapy in pregnancy may be a treatment for multiple or large fetal cardiac rhabdomyomas.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Barnes BT / 2018 / Maternal sirolimus therapy for fetal cardiac rhabdomyomas / N Engl J Med 378:1844~1845
Fesslova V / 2004 / Natural history and long-term outcome of cardiac rhabdomyomas detected prenatally / Prenat Diagn 24:241~248
Breathnach C / 2014 / Rapid regression of left ventricular outflow tract rhabdomyoma after sirolimus therapy / Pediatrics 134:e1199~e1202
Ninic S / 2017 / Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma / Ann Noninvasive Electrocardiol 22:e12435
Demir HA / 2012 / Everolimus : a challenging drug in the treatment of multifocal inoperable cardiac rhabdomyoma / Pediatrics 130:e243~e247
Fesslova V / 2004 / Natural history and long-term outcome of cardiac rhabdomyomas detected prenatally / Prenat Diagn 24:241~248
Breathnach C / 2014 / Rapid regression of left ventricular outflow tract rhabdomyoma after sirolimus therapy / Pediatrics 134:e1199~e1202
Ninic S / 2017 / Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma / Ann Noninvasive Electrocardiol 22:e12435
Demir HA / 2012 / Everolimus : a challenging drug in the treatment of multifocal inoperable cardiac rhabdomyoma / Pediatrics 130:e243~e247
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