지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 113 - 122 (10page)
이용수
초록· 키워드
오류제보하기
Communications at the interface between the apical membrane of follicular cells and the follicular lumen are critical for the homeostasis of thyroid gland. Primary cilia at the apical membrane of thyroid follicular cells may sense follicular luminal environment and regulate follicular homeostasis, although their role in vivo remains to be determined. Here, mice devoid of primary cilia were generated by thyroid follicular epithelial cell-specific deletion of the gene encoding intraflagellar transport protein 88 (Ift88 ). Thyroid follicular cell-specific Ift88-deficient mice showed normal folliculogenesis and hormonogenesis; however, those older than 7 weeks showed irregularly dilated and destroyed follicles in the thyroid gland. With increasing age, follicular cells with malignant properties showing the characteristic nuclear features of human thyroid carcinomas formed papillary and solid proliferative nodules from degenerated thyroid follicles. Furthermore, malignant tumor cells manifested as tumor emboli in thyroid vessels. These findings suggest that loss-of-function of Ift88/primary cilia results in malignant transformation from degenerated thyroid follicles.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Bailey, J. M. / 2009 / Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer / Oncogene 28:3513~3525
Bonura, C. / 1999 / Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas / Hepatology 30:677~681
Cano, D. A. / 2004 / Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization / Development 131:3457~3467
Christensen, S. T. / 2007 / Sensory cilia and integration of signal transduction in human health and disease / Traffic 8:97~109
Degnim, A. C. / 2015 / Gene signature model for breast cancer risk prediction for women with sclerosing adenosis / Breast Cancer Res. Treat 152:687~694
Bonura, C. / 1999 / Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas / Hepatology 30:677~681
Cano, D. A. / 2004 / Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization / Development 131:3457~3467
Christensen, S. T. / 2007 / Sensory cilia and integration of signal transduction in human health and disease / Traffic 8:97~109
Degnim, A. C. / 2015 / Gene signature model for breast cancer risk prediction for women with sclerosing adenosis / Breast Cancer Res. Treat 152:687~694
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Association between nutrient intake and thyroid cancer risk in Korean women
Nutrition Research and Practice
2016 .06
-
Association between nutrient intake and thyroid cancer risk in Korean women
Nutrition Research and Practice
2016 .06
-
Time-Lapse Live-Cell Imaging Reveals Dual Function of Oseg4, Drosophila WDR35, in Ciliary Protein Trafficking
Molecules and Cells
2018 .07
-
Expression of Membrane Fusion Related Genes in Mouse Ovary
대한임상검사과학회지
2016 .01
-
Life of T Follicular Helper Cells
Molecules and Cells
2015 .03
-
Increased Primary Cilia in Idiopathic Pulmonary Fibrosis
Molecules and Cells
2018 .03
-
Expression and Preliminary Functional Profiling of the let-7 Family during Porcine Ovary Follicle Atresia
Molecules and Cells
2015 .04
-
BRAF V600E 돌연변이 검사를 위한 Pyrosequencing 분석법 평가
대한임상검사과학회지
2015 .01
-
정상 갑상샘 기능을 보이는 성인 남성에서 갑상샘 호르몬과 대사증후군 위험요인과의 관계
대한임상검사과학회지
2015 .01
-
Preliminary study of genome-wide association identified novel susceptibility genes for thyroid-related hormones in Chinese population
Genes & Genomics
2022 .08
-
The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly
Molecules and Cells
2017 .06
-
Simultaneous detection of thyroid hormones by immunoreaction-based dual-wavelength capillary electrophoresis
한국분석과학회 학술대회
2017 .11
-
The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate
Molecules and Cells
2017 .04
-
A Correlation Analysis of Serum Creatinine Based eGFR and Serum Cystatin C Based eGFR with Thyroid Dysfunction Patients
대한임상검사과학회지
2017 .01
-
Mechanisms of Weight Control by Primary Cilia
Molecules and Cells
2022 .04
-
Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells
Genes & Genomics
2021 .01
-
중국 성인의 요오드 섭취 실태 및 요오드 급원 식품 섭취 패턴에 따른 특성 비교 - 요오드 영양상태가 다른 세 지역을 중심으로 -
대한지역사회영양학회지
2022 .12
-
SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway
Molecules and Cells
2018 .09
-
Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia
Genes & Genomics
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0