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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 452 - 459 (8page)
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초록· 키워드
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Purpose: To compare the effects of the barrier function in human trabecular meshwork (TM) cells monolayerand the production of nitric oxide (NO) between trabecular outflow drugs, Rho-associated kinase (ROCK) inhibitors,adenosine, and statin.
Methods: Primary cultured TM cells were exposed to 10 or 25 mM Y-27632, 0.1 or 1 mM N6-cyclohexyladenosine(CHA), or 15 or 30 mM simvastatin for 24 hours. NO production and expression of endothelial nitric oxidesynthase mRNA were measured by Griess assay and reverse transcription polymerase chain reaction, respectively.
Barrier functions of the TM cell monolayer were measured by carboxyfluorescein and trans-endothelialelectrical resistance. The expression of matrix metalloproteinase-2 mRNA was assessed with reversetranscription polymerase chain reaction.
Results: In TM cells, treatment with each drug increased endothelial nitric oxide synthase mRNA expression.
Treatment with 25 mM Y-27632 and 1.0 mM CHA increased NO production significantly (p = 0.035 and p = 0.043,respectively). Treatment with each drug increased the permeability (all p = 0.001) and decreased the trans-endothelialelectron resistance of the TM cell monolayer. Treatment with 0.1 mM and 1.0 mM CHA significantlyincreased matrix metalloproteinase-2 mRNA expression, but simvastatin inhibited its expression.
Conclusions: Since treatment with ROCK inhibitor more greatly increased NO production and permeability thandid adenosine or statin, ROCK inhibitor seems to be more effective for lowering intraocular pressure.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Alvarado J / 1984 / Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals / Ophthalmology 91 : 564 ~ 579
Alvarado JA / 2004 / Endothelia of Schlemm’s canal and trabecular meshwork: distinct molecular, functional,
Behar-Cohen FF / 1996 / Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye / Invest Ophthalmol Vis Sci 37 :
Bradley JM / 1998 / Effect of matrix metalloproteinases activity on outflow in perfused human organ culture / Invest Ophthalmol Vis Sci 39 : 2649 ~ 2658
Dismuke WM / 2008 / NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outf low facility involve the BKCa ion channel / Am J Physiol Cell Physi
Alvarado JA / 2004 / Endothelia of Schlemm’s canal and trabecular meshwork: distinct molecular, functional,
Behar-Cohen FF / 1996 / Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye / Invest Ophthalmol Vis Sci 37 :
Bradley JM / 1998 / Effect of matrix metalloproteinases activity on outflow in perfused human organ culture / Invest Ophthalmol Vis Sci 39 : 2649 ~ 2658
Dismuke WM / 2008 / NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outf low facility involve the BKCa ion channel / Am J Physiol Cell Physi
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