지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 530 - 537 (8page)
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초록· 키워드
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Background: Androgenic alopecia (AGA) is the most common type of hair loss. It is likely inherited genetically and is promoted by dihydrotestosterone. 5α-reductase has been proven a good target through finasteride use. However, the pathogenesis of AGA cannot be fully explained based only on dihydrotestosterone levels. Objective: To identify similar hairloss inhibition activity of RE-ORGA with mode of action other than finasteride. Methods: We prepared RE-ORGA from Korean herb mixtures. We performed MTT assays for cytotoxicity, Cell Counting Kit-8 assays for cell proliferation, and western blot to identify expression levels of 5α-reductase and Bax. RNA-sequencing was performed for the expression patterns of genes in dihydrotestosterone-activated pathways. Anti-inflammatory activity was also assessed by the expression levels of tumor necrosis factor-alpha (TNF-α) and interleukin 6. Results: REORGA could promote the proliferation of human dermal papilla cells and showed low cytotoxicity. It also inhibited the expression of 5α-reductases and Bax in the cells. RNA-sequencing results verified that the mRNA expressions of SRD5A1, Bax, transforming growth factor-beta 1 (TGF-β1), and TGF-β1 induced transcript 1 (TGFβ1I1) were decreased, whereas expression of protein tyrosine kinase 2 beta (PTK2β) was more elevated. REORGA also showed anti-inflammatory activity through decreased mRNA levels of TNF-α. Conclusion: Transcriptionally, up-regulation of PTK2β and concomitant down-regulation of TGFβ1I1 imply that RE-ORGA can modulate androgen receptor sensitivity, decreasing the expression of 5α-reductase type II and Bax together with TGF- β1 transcripts; RE-ORGA also showed partial anti-inflammatory activity. Overall, RE-ORGA is expected to alleviate hair loss by regulating 5α-reductase activity and the receptor’s androgen sensitivity.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Courtois M / 1994 / Hair cycle and alopecia / Skin Pharmacol 7:84~89
Choudhry R / 1992 / Localization of androgen receptors in human skin by immunohistochemistry : implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands / J Endocrinol 133:467~475
Hibberts NA / 1998 / Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp / J Endocrinol 156:59~65
Sawaya ME / 1997 / Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia / J Invest Dermatol 109:296~300
Kaufman KD / 1998 / Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group / J Am Acad Dermatol 39(4 Pt 1):578~589
Choudhry R / 1992 / Localization of androgen receptors in human skin by immunohistochemistry : implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands / J Endocrinol 133:467~475
Hibberts NA / 1998 / Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp / J Endocrinol 156:59~65
Sawaya ME / 1997 / Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia / J Invest Dermatol 109:296~300
Kaufman KD / 1998 / Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group / J Am Acad Dermatol 39(4 Pt 1):578~589
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