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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 103 - 111 (9page)
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Objectives: The purpose of this study is to understand the correlations between lung, large intestine, and skin of 3-week-old mice in which ulcerative colitis was induced, up on administration of Coptidis rhizome and Glycyrrhiza uralensis mixed extract. Methods: Mice were divided into 4 groups as follows; no treatment group (Ctrl group), ulcerative colitis-induced mice group (UE group), ulcerative colitis-induced mice group after administering Pentasa (PT group), ulcerative colitis-induced mice group after administering Coptidis rhizoma and Glycyrrhiza uralensis mixed extract (CGT group). Mice were induced ulcerative colitis by Dextran sulfate sodium (DSS). After 5 days of administration, We obvserved anti-inflammatory effect, alveolar formation, and skin barrier control in the colon mucosa. Results: The CGT group was observed arrangement of normal intestinal cells, Infiltration of less inflammatory cells. The CGT significantly decreased positive rseponse of TNF-α, p-IkB, Caspase 3 in large intestine, and significantly increased positive rseponse of EGF, IGF, catalase, Filaggrin, involucrin, loricrin. Conclusions: The results of this study show the correlation of Lung-Large intestine-Skin by administering Coptidis rhizoma and Glycyrrhiza uralensis mixed extract to ulcerative colitis-induced mice.
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참고문헌 (24)
참고문헌 신청
Xavier RJ / 2007 / Unravelling the pathogenesis of inflammatory bowel disease / Nature 448(7152):427~434
Lee JH / 2011 / Inflammatory bowel disease in pediatric age / Korean J Pediatr Gastroenterol Nutr 14(Suppl 1):S34~S41
Yang SK / 2000 / Incidence and prevalence of ulcerative colitis in the Songpa-Kangdong district, Seoul, Korea, 1986-1997 / J Gastroenterol Hepatol 15(9):1037~1042
Yang SK / 2008 / Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005 : a KASID study / Inflamm Bowel Dis 14(4):542~549
Kim YM / 2006 / Clinical characteristics and long-term course of ulcerative colitis in korea / Intest Res 4(1):12~21
Lee JH / 2011 / Inflammatory bowel disease in pediatric age / Korean J Pediatr Gastroenterol Nutr 14(Suppl 1):S34~S41
Yang SK / 2000 / Incidence and prevalence of ulcerative colitis in the Songpa-Kangdong district, Seoul, Korea, 1986-1997 / J Gastroenterol Hepatol 15(9):1037~1042
Yang SK / 2008 / Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005 : a KASID study / Inflamm Bowel Dis 14(4):542~549
Kim YM / 2006 / Clinical characteristics and long-term course of ulcerative colitis in korea / Intest Res 4(1):12~21
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