지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 168 - 174 (7page)
이용수
초록· 키워드
오류제보하기
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, rectal bleeding and diarrhea. Gastrodia elata Blume (GE) has been used for the treatment of various diseases including neurodegenerative diseases and inflammatory disease. However, there has been no information on whether GE regulates intestinal inflammation. The aim of this study is to elucidate whether GE can protect against dextran sulfate sodium (DSS)-induced colitis in a mouse model. The colitis mice were induced by drinking water containing 5% DSS for 7 days. Body weight, colon length and clinical score were assessed to determine the effects on colitis. The levels of inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6 in colitis tissue were also measured. The results showed that mice administrated with DSS showed clinical signs including weight loss and reduced colon length. GE inhibited the DSS-induced loss of body weight and shortening of colon and increased Disease activity index score. Additionally, we observed that GE suppressed the levels of TNF-α and IL-6 in DSS-treated colon tissues. Collectively, these findings provide experimental evidence that GE might be a useful therapeutic agent for patients with UC.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Ardizzone S / 2005 / Biologic therapy for inflammatory bowel disease / Drugs 65 : 2253 ~ 2286
[학술지(정기간행물)] - Bouma G / 2003 / The immunological and genetic basis of inflammatory bowel disease / Nature Reviews Immunology 3 : 521 ~ 533
[학술지(정기간행물)] - Camuesco D / 2005 / Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis / The Journal of Nutrition 135 : 687 ~ 694
[학술지(정기간행물)] - Cooper HS / 1993 / Clinicopathologic study of dextran sulfate sodium experimental murine colitis / Laboratory Investigation 69 : 238 ~ 249
[학술지(정기간행물)] - Danese S / 2004 / Inflammatory bowel disease: the role of environmental factors / Autoimmunity Reviews 3 : 394 ~ 400
[학술지(정기간행물)] - Bouma G / 2003 / The immunological and genetic basis of inflammatory bowel disease / Nature Reviews Immunology 3 : 521 ~ 533
[학술지(정기간행물)] - Camuesco D / 2005 / Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis / The Journal of Nutrition 135 : 687 ~ 694
[학술지(정기간행물)] - Cooper HS / 1993 / Clinicopathologic study of dextran sulfate sodium experimental murine colitis / Laboratory Investigation 69 : 238 ~ 249
[학술지(정기간행물)] - Danese S / 2004 / Inflammatory bowel disease: the role of environmental factors / Autoimmunity Reviews 3 : 394 ~ 400
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UCI(KEPA) : I410-ECN-0101-2018-510-003599293