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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 41 - 45 (5page)
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초록· 키워드
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Objective: The objective of this study was to assess serum, hair, and urinary magnesium (Mg) levels in children with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and both ASD and ADHD to reveal potential interactive effects.
Methods: A total of 148 boys aged 4–9 years old were enrolled in this study, including 44 children with ADHD, 40 pediatric patients with ASD, 32 patients with both ADHD and ASD, as well as 32 healthy neurotypical children. Hair, serum, and urinary Mg levels were assessed using inductively-coupled plasma mass spectrometry (ICP-MS). Laboratory quality control was performed using certified reference materials of human hair, plasma, and urine.
Results: No significant group difference in serum Mg levels was observed. Mg content in hair was found to be reduced in children with ADHD and ADHD+ASD compared to that in healthy controls by 11% and 15%, respectively. Urinary Mg levels in children with ADHD+ASD exceeded the control, ADHD, and ASD values by 51, 76, and 65%, respectively. Factorial analysis revealed significant contribution of ADHD to hair and urinary Mg levels. Multiple regression analysis demonstrated that hair and urinary Mg levels were considered as significant predictors of neurodevelopmental disorder complexity.
Conclusion: We propose that impaired Mg status may provide a link between ADHD and ASD.
Methods: A total of 148 boys aged 4–9 years old were enrolled in this study, including 44 children with ADHD, 40 pediatric patients with ASD, 32 patients with both ADHD and ASD, as well as 32 healthy neurotypical children. Hair, serum, and urinary Mg levels were assessed using inductively-coupled plasma mass spectrometry (ICP-MS). Laboratory quality control was performed using certified reference materials of human hair, plasma, and urine.
Results: No significant group difference in serum Mg levels was observed. Mg content in hair was found to be reduced in children with ADHD and ADHD+ASD compared to that in healthy controls by 11% and 15%, respectively. Urinary Mg levels in children with ADHD+ASD exceeded the control, ADHD, and ASD values by 51, 76, and 65%, respectively. Factorial analysis revealed significant contribution of ADHD to hair and urinary Mg levels. Multiple regression analysis demonstrated that hair and urinary Mg levels were considered as significant predictors of neurodevelopmental disorder complexity.
Conclusion: We propose that impaired Mg status may provide a link between ADHD and ASD.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Thapar A / 2017 / Neurodevelopmental disorders / Lancet Psychiatry 4:339~346
Sayal K / 2018 / ADHD in children and young people: prevalence, care pathways, and service provision / Lancet Psychiatry 5:175~186
Fombonne E / 2018 / The rising prevalence of autism / J Child Psychol Psychiatry 59:717~720
Doernberg E / 2016 / Neurodevelopmental disorders (ASD and ADHD): DSM-5, ICD-10, and ICD-11 / CNS Spectr 21:295~299
Kern JK / 2015 / Are ASD and ADHD a continuum? A comparison of pathophysiological similarities between the disorders / J Atten Disord 19:805~827
Sayal K / 2018 / ADHD in children and young people: prevalence, care pathways, and service provision / Lancet Psychiatry 5:175~186
Fombonne E / 2018 / The rising prevalence of autism / J Child Psychol Psychiatry 59:717~720
Doernberg E / 2016 / Neurodevelopmental disorders (ASD and ADHD): DSM-5, ICD-10, and ICD-11 / CNS Spectr 21:295~299
Kern JK / 2015 / Are ASD and ADHD a continuum? A comparison of pathophysiological similarities between the disorders / J Atten Disord 19:805~827
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UCI(KEPA) : I410-ECN-0101-2020-516-000260712