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논문 기본 정보

자료유형
학술저널
저자정보
Jihyun Kim (Sungkyunkwan University School of Medicine) Seonwoo Kim (Samsung Medical Center) Sook-young Woo (Samsung Medical Center) Jin-Yong Chung (Dong-A University) Young-Seoub Hong (Dong-A University) Se-Young Oh (Kyung Hee University) Suk-Joo Choi (Sungkyunkwan University School of Medicine) Soo-Young Oh (Sungkyunkwan University School of Medicine) Kyung Won Kim (Yonsei University College of Medicine) Youn Ho Shin (CHA University College of Medicine) Hye-Sung Won (University of Ulsan College of Medicine) Kyung-Ju Lee (Korea University Medical College) Soo Hyun Kim (CHA University College of Medicine) Ja Young Kwon (Yonsei University Health System) Si Hyeon Lee (University of Ulsan College of Medicine) Soo-Jong Hong (University of Ulsan College of Medicine) Kangmo Ahn (Sungkyunkwan University School of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.19 No.6
발행연도
2019.12
수록면
82 - 92 (11page)

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There have been few studies investigating the association between atopic dermatitis (AD) and prenatal exposure to heavy metals. We aimed to evaluate whether prenatal exposure to heavy metals is associated with the development or severity of AD in a birth cohort study. A total of 331 subjects were followed from birth for a median duration of 60.0 months. The presence and severity of AD were evaluated at ages 6 and 12 months, and regularly once a year thereafter. The concentrations of lead, mercury, chromium, and cadmium in umbilical cord blood were measured by inductively coupled plasma mass spectrometry. Cord blood mononuclear cells (CBMCs) were isolated and stimulated for analysis of cytokine production using ELISA. Heavy metal levels in cord blood were not associated with the development of AD until 24 months of age. However, a positive correlation was observed between the duration of AD and lead levels in cord blood (p=0.002). AD severity was also positively associated with chromium concentrations in cord blood (p=0.037), while cord blood levels of lead, mercury, and cadmium were not significantly associated with AD severity (p=0.562, p=0.054, and p=0.055, respectively). Interleukin-13 production in CBMCs was positively related with lead and chromium levels in cord blood (p=0.021 and p=0.015, respectively). Prenatal exposure to lead and chromium is associated with the persistence and severity of AD, and the immune reaction toward a Th2 polarization.
#Dermatitis, atopic #Cohort studies #Chromium #Fetal blood #Interleukin-13

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (34)

참고문헌 신청
Kim CH / 2017 / Association of maternal depression and allergic diseases in Korean children / Allergy Asthma Proc 38:300~308 google schola Yang HK / 2016 / The association between hypovitaminosis D and pediatric allergic diseases: a Korean nationwide population-based study / Allergy Asthma Proc 37:64~69 google schola 정영희 / 2012 / Retrospective Analysis of the Natural History of Atopic Dermatitis Occurring in the First Year of Life in Korean Children / Journal of Korean Medical Science 27(7):723~728 dbpia Kapur S / 2018 / Atopic dermatitis / Allergy Asthma Clin Immunol 14:52 google schola Ahn K / 2014 / The role of air pollutants in atopic dermatitis / J Allergy Clin Immunol 134:993~999 google schola

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