지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 59 - 73 (15page)
이용수
초록· 키워드
오류제보하기
The γδ T cells are unconventional lymphocytes that function in both innate and adaptive immune responses against various intracellular and infectious stresses. The γδ T cells can be exploited as cancer-killing effector cells since γδ TCRs recognize MHC-like molecules and growth factor receptors that are upregulated in cancer cells, and γδ T cells can differentiate into cytotoxic effector cells. However, γδ T cells may also promote tumor progression by secreting IL-17 or other cytokines. Therefore, it is essential to understand how the differentiation and homeostasis of γδ T cells are regulated and whether distinct γδ T cell subsets have different functions. Human γδ T cells are classified into Vδ2 and non-Vδ2 γδ T cells. The majority of Vδ2 γδ T cells are Vγ9δ2 T cells that recognize pyrophosphorylated isoprenoids generated by the dysregulated mevalonate pathway. In contrast, Vδ1 T cells expand from initially diverse TCR repertoire in patients with infectious diseases and cancers. The ligands of Vδ1 T cells are diverse and include the growth factor receptors such as endothelial protein C receptor. Both Vδ1 and Vδ2 γδ T cells are implicated to have immunotherapeutic potentials for cancers, but the detailed elucidation of the distinct characteristics of 2 populations will be required to enhance the immunotherapeutic potential of γδ T cells. Here, we summarize recent progress regarding cancer immunology of human γδ T cells, including their development, heterogeneity, and plasticity, the putative mechanisms underlying ligand recognition and activation, and their dual effects on tumor progression in the tumor microenvironment.
목차
ABSTRACT
INTRODUCTION
ORIGIN AND DEVELOPMENT OF THE HUMAN γδ T CELLS
HETEROGENEITY OF THE HUMAN γδ T CELLS
THE γδ TCR STRUCTURE AND ACTIVATION OF THE HUMAN γδ T CELLS
THE γδ T CELLS IN THE TUMOR MICROENVIRONMENT(TME)
FUTURE DIRECTIONS FOR OPTIMIZING ADOPTIVE γδ T CELL TRANSFER AS AN ALTERNATIVE CANCER IMMUNOTHERAPY
CONCLUDING REMARKS
REFERENCES
참고문헌 (113)
참고문헌 신청
Vantourout P / 2013 / Six-of-the-best : unique contributions of γδ T cells to immunology / Nat Rev Immunol 13:88~100
Adams EJ / 2015 / Human gamma delta T cells : evolution and ligand recognition / Cell Immunol 296:31~40
Chien YH / 2014 / γδ T cells : first line of defense and beyond / Annu Rev Immunol 32:121~155
Stolk D / 2018 / Positive & negative roles of innate effector cells in controlling cancer progression / Front Immunol 9:1990
Girardi M / 2001 / Regulation of cutaneous malignancy by gammadelta T cells / Science 294:605~609
Adams EJ / 2015 / Human gamma delta T cells : evolution and ligand recognition / Cell Immunol 296:31~40
Chien YH / 2014 / γδ T cells : first line of defense and beyond / Annu Rev Immunol 32:121~155
Stolk D / 2018 / Positive & negative roles of innate effector cells in controlling cancer progression / Front Immunol 9:1990
Girardi M / 2001 / Regulation of cutaneous malignancy by gammadelta T cells / Science 294:605~609
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Murine γδ T Cells Render B Cells Refractory to Commitment of IgA Isotype Switching
Immune Network
2018 .08
-
Distribution of Interleukin-22–secreting Immune Cells in Conjunctival Associated Lymphoid Tissue
Korean Journal of Ophthalmology
2018 .01
-
Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
Investigative and Clinical Urology
2019 .01
-
Aberrant Loss of Surface CD3 and TCRγδ Expression in Relapsed Hepatosplenic T-cell Lymphoma
Annals of Laboratory Medicine
2021 .11
-
Lineage differentiation of innate T cell
한국실험동물학회 학술발표대회 논문집
2019 .07
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Vγ1+ γδT Cells Are Correlated With Increasing Expression of Eosinophil Cationic Protein and Metalloproteinase-7 in Chronic Rhinosinusitis With Nasal Polyps Inducing the Formation of Edema
Allergy, Asthma & Immunology Research
2017 .01
-
Hepatic serum amyloid A1 has the capacity to accelerate psoriatic symptoms by increasing IL-17 levels from γδ T cells in transgenic mice
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Marked Increase of Circulating Double-Negative γδ T Cells in a Patient With Hydroa Vacciniforme-Like Lymphoma
Annals of Laboratory Medicine
2016 .01
-
Mitochondrial dsRNA-mediated TLR3 activation in Kupffer cells through exosome
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Primary Peripheral Gamma Delta T-Cell Lymphoma of the Central Nervous System: Report of a Case Involving the Intramedullary Spinal Cord and Presenting with Myelopathy
Journal of Pathology and Translational Medicine
2019 .01
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Lineage Differentiation Program of Invariant Natural Killer T Cells
Immune Network
2017 .12
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
Mitochondrial dsRNA and TLR3 in hepatic inflammation
한국실험동물학회 학술발표대회 논문집
2021 .07
-
유방암 줄기세포 개념 및 제한점
의생명과학
2018 .01
-
Role of PD-1 expressed on regulatory T cells during cancer progression
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Anticancer Drugs at Low Concentrations Upregulate the Activity of Natural Killer Cell
대한의생명과학회지
2023 .09
-
Tumor Induces the Expansion of Foxp3+CD25high and CD11b+Gr-1+ Cell Population in the Early Phase of Tumor Progression
대한의생명과학회지
2015 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0