지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 147 - 153 (7page)
이용수
초록· 키워드
오류제보하기
Interleukin (IL)-22 is a cytokine involved in epithelial cell regeneration. Currently, no research studieshave analyzed the distribution of the three distinct IL-22–secreting cell populations in human or mouse conjunctiva. This study investigated the distribution of the three main populations of IL-22–secreting immune cells, αβ Thcells, γδ T cells, or innate cells (innate lymphoid cells [ILCs] or natural killer cells), in conjunctival associated lymphoidtissues (CALTs) in human and mouse models. Methods: We collected discarded cadaveric bulbar conjunctival tissue specimens after preservation of the corneo-limbal tissue for keratoplasty from four enucleated eyes of the domestic donor. The bulbar conjunctivatissue, including the cornea from normal (n = 27) or abraded (n = 4) B6 mice, were excised and pooled in RPMI1640 media. After the lymphoid cells were gated in forward and side scattering, the αβ Th cells, γδ T cells, orinnate lymphoid cells were positively or negatively gated using anti-CD3, anti-γδ TCR, and anti–IL-22 antibodies,with a FACSCanto flow cytometer. Results: In normal human conjunctiva, the percentage and number of cells were highest in αβ Th cells, followed byγδ T cells and CD3– γδ TCR – IL-22+ innate cells (presumed ILCs, pILCs) (Kruskal-Wallis test, p = 0.012). In normalmice keratoconjunctiva, the percentage and total number were highest in γδ T cells, followed by αβ Th cellsand pILCs (Kruskal-Wallis test, p = 0.0004); in corneal abraded mice, the population of αβ Th cells and pILCstended to increase. Conclusions: This study suggests that three distinctive populations of IL-22–secreting immune cells are presentin CALTs of both humans and mice, and the proportions of IL-22+αβ Th cells, γδ T cells, and pILCs in CALTs inhumans might be differently distributed from those in normal mice.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity
Immune Network
2020 .02
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Murine γδ T Cells Render B Cells Refractory to Commitment of IgA Isotype Switching
Immune Network
2018 .08
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Lineage Differentiation Program of Invariant Natural Killer T Cells
Immune Network
2017 .12
-
Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues
Immune Network
2016 .04
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
Investigative and Clinical Urology
2019 .01
-
Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
Immune Network
2018 .02
-
Unusual Suspects in the Development of Obesity- Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs
Diabetes and Metabolism Journal
2017 .01
-
Innate Immunological Function of Bystander CD4 T Cells in Autoimmunity
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Osteopontin Potentiates Pulmonary Inflammation and Fibrosis by Modulating IL-17/IFN-γ-secreting T-cell Ratios in Bleomycin-treated Mice
Immune Network
2015 .06
-
Aberrant Loss of Surface CD3 and TCRγδ Expression in Relapsed Hepatosplenic T-cell Lymphoma
Annals of Laboratory Medicine
2021 .11
-
Hepatic serum amyloid A1 has the capacity to accelerate psoriatic symptoms by increasing IL-17 levels from γδ T cells in transgenic mice
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Th17 Cell and Inflammatory Infiltrate Interactions in Cutaneous Leishmaniasis: Unraveling Immunopathogenic Mechanisms
Immune Network
2024 .04
-
Innate Lymphoid Cells and Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .06
-
Cytotoxicity of natural killer cells co-cultured with γ-irradiatedor mitomycin C-treated feeder cells
예방수의학회지
2020 .01
-
Heterogeneity of Islet Cells during Embryogenesis and Differentiation
Diabetes and Metabolism Journal
2023 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0