지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.98 No.4
- 발행연도
- 2020.4
- 수록면
- 159 - 167 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: We investigated the expression of Nrf2 in colorectal cancer and its correlation with clinicopathological characteristics as well as mechanisms and roles of Nrf2 expression including cell signaling pathway, survival, proliferation, and migration.
Methods: Nrf2 expression was measured in 12 and 30 different colorectal cancer (CRC) tissues by western blot (WB) and immunohistochemistry (IHC), respectively. SW480 cells were used for cell proliferation and cell migration tests. The correlation between the expression of Nrf2 and clinicopathologic parameters were evaluated using the chi-square or Fisher exact test. Data are expressed as the mean ± standard deviation for 3 independent experiments. P < 0.05 was considered statistically significant.
Results: Analysis of WB demonstrated that Nrf2 proteins were increased in CRC tissues, and decreased in normal tissues. IHC staining showed that the Nrf2 expression was elevated in CRC tissues, compared to matched normal tissues. When SW480 cells were suppressed with small interfering RNA of Nrf2, cell viability was inhibited, and cell apoptosis was increased. These results were found along with suppression of the phosphorylated form of extracellular signal-regulated kinase 1/2 and AKT.
Conclusion: This study suggests that overexpression of Nrf2 may be related to carcinogenesis and progression of CRC.
Methods: Nrf2 expression was measured in 12 and 30 different colorectal cancer (CRC) tissues by western blot (WB) and immunohistochemistry (IHC), respectively. SW480 cells were used for cell proliferation and cell migration tests. The correlation between the expression of Nrf2 and clinicopathologic parameters were evaluated using the chi-square or Fisher exact test. Data are expressed as the mean ± standard deviation for 3 independent experiments. P < 0.05 was considered statistically significant.
Results: Analysis of WB demonstrated that Nrf2 proteins were increased in CRC tissues, and decreased in normal tissues. IHC staining showed that the Nrf2 expression was elevated in CRC tissues, compared to matched normal tissues. When SW480 cells were suppressed with small interfering RNA of Nrf2, cell viability was inhibited, and cell apoptosis was increased. These results were found along with suppression of the phosphorylated form of extracellular signal-regulated kinase 1/2 and AKT.
Conclusion: This study suggests that overexpression of Nrf2 may be related to carcinogenesis and progression of CRC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Siegel R / 2014 / Colorectal cancer statistics, 2014 / CA Cancer J Clin 64:104~117
Gallagher DJ / 2010 / Metastatic colorectal cancer : from improved survival to potential cure / Oncology 78:237~248
Breimer LH / 1990 / Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis : the role of DNA base damage / Mol Carcinog 3:188~197
Kobayashi M / 2002 / Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system / Genes Cells 7:807~820
Zhang DD / 2006 / Mechanistic studies of the Nrf2-Keap1 signaling pathway / Drug Metab Rev 38:769~789
Gallagher DJ / 2010 / Metastatic colorectal cancer : from improved survival to potential cure / Oncology 78:237~248
Breimer LH / 1990 / Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis : the role of DNA base damage / Mol Carcinog 3:188~197
Kobayashi M / 2002 / Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system / Genes Cells 7:807~820
Zhang DD / 2006 / Mechanistic studies of the Nrf2-Keap1 signaling pathway / Drug Metab Rev 38:769~789
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Nrf2 expression by bisphenol A and its substitutes regulates human B cell survival
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2023 .06
-
Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue
Annals of Dermatology
2015 .01
-
저칼륨혈증 흰쥐 신장에서 Nrf2와 p-Nrf2 단백발현의 변화
해부·생물인류학
2015 .03
-
MicroRNA-based diagnosis and therapy in NRF2-stabilized tumor
대한동의병리학회 학술대회논문집
2015 .10
-
The regulation of p62-Nrf2-Keap1 axis in dysregulation of lipid metabolism
대한동의병리학회 학술대회논문집
2015 .10
-
The Role of Genetic Polymorphisms in Nrf2 and P73 in Egyptian Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-kB and MAPK-Nrf2/NF-kB pathways
Journal of Ginseng Research
2022 .07
-
MicroRNA-362 Inhibits Cell Proliferation and Invasion by Directly Targeting SIX1 in Colorectal Cancer
Yonsei Medical Journal
2019 .01
-
Oxidative Stress, Nrf2, and Epigenetic Modification Contribute to Anticancer Drug Resistance
Toxicological Research
2017 .01
-
대장암 동물 모델에 대한 이해
의생명과학
2018 .01
-
Editorial : Registration candidate journal of national research foundation (NRF)
대한방사성의약품학회지
2018 .01
-
Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
청조구폐탕(淸燥救肺湯)의 Nrf2 매개 항산화 효능
동의생리병리학회지
2015 .01
-
淸燥救肺湯의 Nrf2 매개 항산화 효능
동의생리병리학회지
2015 .04
-
Attitudes Towards Colorectal Cancer (CRC) and CRC Screening Tests among Elderly Malay Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Age-related Changes in the Sirtuin1-NFE2-related Factor 2 Signaling System in the Kidney
대한내과학회지
2017 .01
-
Rhein suppresses colorectal cancer cell growth by inhibiting the mTOR pathway in vitro and in vivo
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-κB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-514-000533281