지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Xerostomia is a relatively common oral disease that causes various problems such as pain, discomforted, tissue damage, and infection. When the activity of AQPs, which plays an important role in the microbial channel transmembrane activity in tissues, decreases saliva secretion and the oral cavity dryness occurs. In this study, we observed whether there was a change in tissue through the expression level of AQP-5 in the submandibular gland in the 4-DAMP-induced xerostomia model. First, in order to construct a xerostomia model, 4-DAMP (1 mg/kg) and 20% urethane (0.5 mL/kg) were administered intraperitoneal (i.p.) to experimental animals. To observe the changes in the submandibular gland was excised, H&E staining was performed and protein quantitation analysis was performed using the submandibular tissue to observe the changes in AQP5 protein expression involved in changes in saliva secretion. Also, cinnamaldehyde (5, 12.5, 25 and 50 mg/kg) dissolved in 20% DMSO, in distilled water for each concentration, and then orally administered at a dose of 1 mL for biopsy and protein quantitative analysis. As a result, it was observed that the submandibular tissue, a model of xerostomia was wider than the naïve group. And then western blot analysis, the expression level of AQP5 decreased in the 4-DAMP group compared to the naïve group, and the expression increased in the group administered orally with cinnamaldehyde. Therefore, administration of 4-DAMP resulted in histological changes for xerostomia, and cinnamaldehyde would be a material that can be developed by reducing xerostomia.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (22)
참고문헌 신청
Aframian DJ / 2007 / Pilocarpine treatment in a mixed cohort of xerostomic patients / Oral Dis 13:88~92
Agre P / 2002 / Aquaporin water channels-from atomic structure to clinical medicine / J Physiol 542:3~16
Braga MA / 2009 / Comparison of the effects of pilocarpine and cevimeline on salivary flow / Int J Dent Hyg 7:126~130
Caulfueld MP / 1998 / International union of pharmacology. XVII. Classification of muscarinic acetylcholine receptors / Pharmacol Rev. 50:279~290
최정석 / 2016 / 구강건조증의 진단과 치료 / 대한이비인후-두경부외과학회지 59(6):424~429
Agre P / 2002 / Aquaporin water channels-from atomic structure to clinical medicine / J Physiol 542:3~16
Braga MA / 2009 / Comparison of the effects of pilocarpine and cevimeline on salivary flow / Int J Dent Hyg 7:126~130
Caulfueld MP / 1998 / International union of pharmacology. XVII. Classification of muscarinic acetylcholine receptors / Pharmacol Rev. 50:279~290
최정석 / 2016 / 구강건조증의 진단과 치료 / 대한이비인후-두경부외과학회지 59(6):424~429
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UCI(KEPA) : I410-ECN-0101-2020-510-000849662