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논문 기본 정보

자료유형
학술저널
저자정보
Sung Sil Park (National Cancer Center) Bun Kim (National Cancer Center) Min Jung Kim (National Cancer Center) Seung Jae Roh (National Cancer Center) Sung Chan Park (National Cancer Center) Byung Chang Kim (National Cancer Center) Kyung Su Han (National Cancer Center) Chang Won Hong (National Cancer Center) Dae Kyung Sohn (National Cancer Center) Jae Hwan Oh (National Cancer Center)
저널정보
대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.1
발행연도
2020.7
수록면
44 - 51 (8page)

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Purpose: Although many studies have evaluated the association between intestinal microorganisms and the risk of colorectal cancer (CRC), only a few studies have investigated the changes in microorganisms following curative treatment for CRC. The current study analyzed changes in intestinal microbiota following curative surgery in CRC patients.
Methods: Stool samples were collected before and 6 months after surgery, from 11 patients with clinical stage III CRC, who underwent curative surgery between May 2017 and June 2017. Next, 16S rRNA gene sequencing was performed. Operational taxonomic units (OTUs) and alpha diversity were evaluated using the Shannon index. The bacterial compositions of the stools were analyzed according to taxonomic rank at genus and phylum levels.
Results: OTUs and alpha diversity were significantly decreased following surgery (P < 0.001 and P = 0.019, respectively). The compositions of several bacterial taxa changed after surgery. At genus level, proportions of pathogens such as Campylobacter, Fusobacterium, Haemophilus, Porphyromonas, and Prevotella, decreased after surgery (adjusted P < 0.05). At phylum level, the proportion of Fusobacteria decreased after surgery (adjusted P < 0.001).
Conclusion: Significant changes in intestinal microbial communities were noted following curative resection of CRC patients. Especially, decreases in pathogenic bacterial populations, such as Fusobacterium and Prevotella, which are known to be associated with CRC development, were detected even though OTUs and alpha diversity were decreased following curative resection. To determine and validate the clinical significance of these findings, large scale, prospective studies that include cancer prognoses are required.
#Colorectal neoplasms #Gut microbiota #Surgery

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INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (30)

참고문헌 신청
Uhry Z / 2013 / National cancer incidence is estimated using the incidence/mortality ratio in countries with local incidence data : is this estimation correct / Cancer Epidemiol 37:270~277 google schola 김진천 / 2005 / 대장암의 유전병인 / Annals of Surgical Treatment and Research 69(3):189~198 dbpia Berstad P / 2015 / Long-term lifestyle changes after colorectal cancer screening : randomised controlled trial / Gut 64:1268~1276 google schola Sun J / 2016 / Gut microbiota, inflammation and colorectal cancer. Version 2 / Genes Dis 3:130~143 google schola Chen HM / 2013 / Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma / Am J Clin Nutr 97:1044~1052 google schola

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