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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 266 - 271 (6page)
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초록· 키워드
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Breast cancer encompasses a major portion of human cancers and must be carefully monitored for appropriate diagnoses and treatments. Among the many types of breast cancers, triple negative breast cancer (TNBC) has the worst prognosis and the least cases reported. To gain a better understanding and a more decisive precursor for TNBC, two major histone modifications, an activating modification H3K4me3 and a repressive modification H3K27me3, were analyzed using data from normal breast cell lines against TNBC cell lines. The combination of these two histone markers on the gene promoter regions showed a great correlation with gene expression. A list of signature genes was defined as active (highly enriched H3K4me3), including NOVA1, NAT8L, and MMP16, and repressive genes (highly enriched H3K27me3), IRX2 and ADRB2, according to the distribution of these histone modifications on the promoter regions. To further enhance the investigation, potential candidates were also compared with other types of breast cancer to identify signs specific to TNBC. RNA-seq data was implemented to confirm and verify gene regulation governed by the histone modifications. Combinations of the biomarkers based on H3K4me3 and H3K27me3 showed the diagnostic value AUC 93.28% with P-value of 1.16e-226. The results of this study suggest that histone modification analysis of opposing histone modifications may be valuable toward developing biomarkers and targets for TNBC.
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참고문헌 (18)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
O'Brien KM / 2010 / Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study / Clin Cancer Res 16:6100~6110
Perou CM / 2011 / Molecular stratification of triple-negative breast cancers / Oncologist 16(Suppl 1):61~70
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295:2492~2502
Jones PA / 2007 / The epigenomics of cancer / Cell 128:683~692
O'Brien KM / 2010 / Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study / Clin Cancer Res 16:6100~6110
Perou CM / 2011 / Molecular stratification of triple-negative breast cancers / Oncologist 16(Suppl 1):61~70
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295:2492~2502
Jones PA / 2007 / The epigenomics of cancer / Cell 128:683~692
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