지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 1 - 9 (9page)
- DOI
- 10.1038/s12276-020-0382-4
이용수
초록· 키워드
오류제보하기
The interaction between histones and DNA is important for eukaryotic gene expression. A loose interaction caused, for example, by the neutralization of a positive charge on the histone surface by acetylation, induces a less compact chromatin structure, resulting in feasible accessibility of RNA polymerase and increased gene expression. In contrast, the formation of a tight chromatin structure due to the deacetylation of histone lysine residues on the surface by histone deacetylases enforces the interaction between the histones and DNA, which minimizes the chance of RNA polymerases contacting DNA, resulting in decreased gene expression. Therefore, the balance of the acetylation of histones mediated by histone acetylases (HATs) and histone deacetylases (HDACs) is an issue of transcription that has long been studied in relation to posttranslational modification. In this review, current knowledge of HDACs is briefly described with an emphasis on recent progress in research on HDACs, especially on class IIa HDACs.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Modulation of gene expression dynamics by co-transcriptional histone methylations
Experimental and Molecular Medicine
2017 .01
-
Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression
BMB Reports
2018 .01
-
Identification of small molecules that inhibit the histone chaperone Asf1 and its chromatin function
BMB Reports
2015 .01
-
Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy
BMB Reports
2015 .01
-
HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape
Experimental and Molecular Medicine
2024 .02
-
Trans-tail regulation-mediated suppression of cryptic transcription
Experimental and Molecular Medicine
2021 .11
-
LSD1: more than demethylation of histone lysine residues
Experimental and Molecular Medicine
2020 .12
-
유전자재조합 CHO 세포에서 Histone Deacetylase Inhibitor를 이용한 Albumin-erythropoietin 생산성 증진
KSBB Journal
2015 .02
-
Direct Conversion of Human Fibroblasts to Functional Osteoblasts Using a Histone Deacetylase Inhibiting Small Molecule
한국생물공학회 학술대회
2020 .10
-
The Synergistic Anti-cancer Effect of Histone Deacetylase Inhibitor and Temozolomide in Various Glioblastoma Cell Lines
한국생물공학회 학술대회
2024 .09
-
Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway
BMB Reports
2017 .01
-
Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for TNBC and gene set prediction combination
BMB Reports
2020 .01
-
Writing, erasing and reading histone lysine methylations
Experimental and Molecular Medicine
2017 .01
-
Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification
Experimental and Molecular Medicine
2019 .01
-
Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
BMB Reports
2017 .01
-
Epigenetic regulation and chromatin remodeling in learning and memory
Experimental and Molecular Medicine
2017 .01
-
Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker
Experimental and Molecular Medicine
2017 .01
-
Histone lysine demethylases in mammalian embryonic development
Experimental and Molecular Medicine
2017 .01
-
플라즈몬 나노 입자의 광학적 특성을 활용한 세포 노화 측정에 대한 수치적 연구
대한기계학회 춘추학술대회
2021 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0