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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 9 (9page)
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Co-transcriptional methylations of histone H3 at lysines 4 and 36, highly conserved methyl marks from yeast to humans, have profound roles in regulation of histone acetylation. These modifications function to recruit and/or activate distinct histone acetyltransferases (HATs) or histone deacetylases (HDACs). Whereas H3K4me3 increases acetylation at promoters via multiple HATs, H3K4me2 targets Set3 HDAC to deacetylate histones in 5′ transcribed regions. In 3′ regions of genes, H3K36me2/3 facilitates deacetylation by Rpd3S HDAC and slows elongation. Despite their important functions in deacetylation, no strong effects on global gene expression have been seen under optimized or laboratory growth conditions. Instead, H3K4me2-Set3 HDAC and Set2-Rpd3S pathways primarily delay the kinetics of messenger RNA (mRNA) and long noncoding RNA (lncRNA) induction upon environmental changes. A majority of mRNA genes regulated by these pathways have an overlapping lncRNA transcription either from an upstream or an antisense promoter. Surprisingly, the distance between mRNA and lncRNA promoters seems to specify the repressive effects of the two pathways. Given that co-transcriptional methylations and acetylation have been linked to many cancers, studying their functions in a dynamic condition or during cancer progression will be much more important and help identify novel genes associated with cancers.
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참고문헌 (27)
참고문헌 신청
Barbaric S / 2001 / Increasing the rate of chromatin remodeling and gene activation?a novel role for the histone acetyltransferase Gcn5 / EMBO J 20 : 4944 ~ 4951
Barski A / 2007 / Highresolution profiling of histone methylations in the human genome / Cell 129 : 823 ~ 837
Buratowski S / 2009 / Progression through the RNA polymerase II CTD cycle / Mol Cell 36 : 541 ~ 546
Buratowski S / 2010 / The role of cotranscriptional histone methylations / Cold Spring Harb Symp Quant Biol 75 : 95 ~ 102
Dehe PM / 2005 / Histone H3 lysine 4 mono-methylation does not require ubiquitination of histone H2B / J Mol Biol 353 : 477 ~ 484
Barski A / 2007 / Highresolution profiling of histone methylations in the human genome / Cell 129 : 823 ~ 837
Buratowski S / 2009 / Progression through the RNA polymerase II CTD cycle / Mol Cell 36 : 541 ~ 546
Buratowski S / 2010 / The role of cotranscriptional histone methylations / Cold Spring Harb Symp Quant Biol 75 : 95 ~ 102
Dehe PM / 2005 / Histone H3 lysine 4 mono-methylation does not require ubiquitination of histone H2B / J Mol Biol 353 : 477 ~ 484
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