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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 479 - 490 (12page)
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Interleukin-9 (IL-9) is well known for its role in allergic inflammation. For cancer, both pro- and anti-tumor effects of IL-9 were controversially reported, but the impact of IL-9 on tumor metastasis has not yet been clarified. In this study, IL-9 was expressed as a secretory form (sIL-9) and a membrane-bound form (mbIL-9) on B16F10 melanoma cells. The mbIL-9 was engineered as a chimeric protein with the transmembrane and cytoplasmic region of TNF-α. The effect of either mbIL-9 or sIL-9 expressing cells were analyzed on the metastasis capability of the cancer cells. After three weeks of tumor implantation into C57BL/6 mice through the tail vein, the number of tumor modules in lungs injected with IL-9 expressing B16F10 was 5-fold less than that of control groups. The percentages of CD4+ T cells, CD8+ T cells, NK cells, and M1 macrophages considerably increased in the lungs of the mice injected with IL-9 expressing cells. Among them, the M1 macrophage subset was the most significantly enhanced. Furthermore, peritoneal macrophages, which were stimulated with either sIL-9 or mbIL-9 expressing transfectant, exerted higher anti-tumor cytotoxicity compared with that of the mock control. The IL-9-stimulated peritoneal macrophages were highly polarized to M1 phenotype. Stimulation of RAW264.7 macrophages with sIL-9 or mbIL-9 expressing cells also significantly increased the cytotoxicity of those macrophages against wild-type B16F10 cells. These results clearly demonstrate that IL-9 can induce an anti-metastasis effect by enhancing the polarization and proliferation of M1 macrophages.
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참고문헌 (37)
참고문헌 신청
Chakraborty, S. / 2019 / An update on interleukin-9 : from its cellular source and signal transduction to its role in immunopathogenesis / Int. J. Mol. Sci 20:e2113
Chang, H. C. / 2010 / The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation / Nat. Immunol 11:527~534
Ciccia, F. / 2015 / Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis / Rheumatology(Oxford) 54:2264~2272
Conway, E. M. / 2016 / Macrophages, inflammation, and lung cancer / Am. J. Respir. Crit. Care Med 193:116~130
Dantas, A. T. / 2015 / Increased serum interleukin-9 levels in rheumatoid arthritis and systemic lupus erythematosus: pathogenic role or just an epiphenomenon? / Dis. Markers 2015:519638
Chang, H. C. / 2010 / The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation / Nat. Immunol 11:527~534
Ciccia, F. / 2015 / Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis / Rheumatology(Oxford) 54:2264~2272
Conway, E. M. / 2016 / Macrophages, inflammation, and lung cancer / Am. J. Respir. Crit. Care Med 193:116~130
Dantas, A. T. / 2015 / Increased serum interleukin-9 levels in rheumatoid arthritis and systemic lupus erythematosus: pathogenic role or just an epiphenomenon? / Dis. Markers 2015:519638
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