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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,204 - 1,210 (7page)
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Purpose: Glucocorticoids, stress-related hormones, inhibit hair growth. Intracellular glucocorticoid availability is regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD1 was recently detected in keratinocytes and fibroblasts. However, the expression of 11β-HSD1 in human hair follicles remains unknown. We aimed to examine 11β-HSD1 expression in human dermalpapilla cells (DPCs) and to investigate whether modulation of 11β-HSD1 activity can regulate the negative effects of glucocorticoidson DPCs.
Materials and Methods: 11β-HSD1 expression in normal human scalp skin was examined by immunohistochemistry. 11β-HSD1 protein was detected in Western blots of human DPCs. Cultured human DPCs were treated with cortisol with or without a selective 11β-HSD1 inhibitor and subsequently stained for Ki-67 antibody. Expression levels of 11β-HSD1, Wnt5a, alkaline phosphatase (ALP), and vascular endothelial growth factor (VEGF) were analyzed by Western blotting.
Results: 11β-HSD1 was detected in dermal papilla in human scalp skin by immunohistochemistry. Human DPCs expressed 11β-HSD1 protein in vitro. Furthermore, cortisol stimulated the expression of 11β-HSD1 in DPCs. Glucocorticoids decreased cellularproliferation and the expression of Wnt5a, ALP, and VEGF in DPCs. A specific 11β-HSD1 inhibitor significantly attenuated the anti-proliferative effects of cortisol and reversed the cortisol-induced suppression of Wnt5a, ALP, and VEGF expression in DPCs.
Conclusion: Our data demonstrated the expression of 11β-HSD1 in human DPCs and revealed that inhibition of 11β-HSD1 activity can partially prevent the negative effect of glucocorticoids on DPCs, suggesting the possible application of 11β-HSD1 inhibitors for stress-related hair loss.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alexopoulos A / 2016 / Stress-related skin disorders / Rev Endocr Metab Disord 17 : 295 ~ 304
Botchkarev VA / 2003 / Stress and the hair follicle: exploring the connections / Am J Pathol 162 : 709 ~ 712
Choi EH / 2006 / Glucocorticoid blockade reverses psychological stressinduced abnormalities in epidermal structure and function / Am J Physiol Regul Integr Comp Physiol 291 :
Choi SJ / 2013 / Effects of glucocorticoid on human dermal papilla cells in vitro / J Steroid Biochem Mol Biol 135 : 24 ~ 29
Demerjian M / 2009 / Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis / Exp Dermatol 18 : 643 ~ 649
Botchkarev VA / 2003 / Stress and the hair follicle: exploring the connections / Am J Pathol 162 : 709 ~ 712
Choi EH / 2006 / Glucocorticoid blockade reverses psychological stressinduced abnormalities in epidermal structure and function / Am J Physiol Regul Integr Comp Physiol 291 :
Choi SJ / 2013 / Effects of glucocorticoid on human dermal papilla cells in vitro / J Steroid Biochem Mol Biol 135 : 24 ~ 29
Demerjian M / 2009 / Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis / Exp Dermatol 18 : 643 ~ 649
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