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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 197 - 203 (7page)
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Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation.Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group) as follows: allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation.Results: Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506-L group were viable and functioning post-transplantation. Conclusion: The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major differ-ence in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Jacobsen HC / 2013 / Allogenic submandibular gland transplantation following hematopoietic stem cell transplantation / J Craniomaxillofac Surg 41:764~769
Wallemacq PE / 1993 / FK506(tacrolimus), a novel immunosuppressant in organ transplantation : clinical, biomedical, and analytical aspects / Clin Chem 39(11 Pt 1):2219~2228
Wang MS / 1997 / Comparative dosedependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve / J Pharmacol Exp Ther 282:1084~1093
Geerling G / 2008 / Innervation and secretory function of transplanted human submandibular salivary glands / Transplantation 85:135~140
Giessler GA / 2007 / Severe tacrolimus toxicity in rabbits / Exp Clin Transplant 5:590~595
Wallemacq PE / 1993 / FK506(tacrolimus), a novel immunosuppressant in organ transplantation : clinical, biomedical, and analytical aspects / Clin Chem 39(11 Pt 1):2219~2228
Wang MS / 1997 / Comparative dosedependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve / J Pharmacol Exp Ther 282:1084~1093
Geerling G / 2008 / Innervation and secretory function of transplanted human submandibular salivary glands / Transplantation 85:135~140
Giessler GA / 2007 / Severe tacrolimus toxicity in rabbits / Exp Clin Transplant 5:590~595
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