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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 886 - 895 (10page)
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Purpose This study was conducted to evaluate the prognostic values of the 7th and 8th American Joint Committee on Cancer (AJCC) staging systems for patients with resected perihilar cholangiocarcinoma (PHCC). Materials and Methods A total of 348 patients who underwent major hepatectomy for PHCC between 2008 and 2015 were identified from a single center. Overall survival (OS) was estimated using the Kaplan-Meier method and compared across stage groups with the log-rank test. The concordance index was used to evaluate the prognostic predictability of the 8th AJCC staging system compared with that of the 7th. Results In the 8th edition, the stratification of each group of T classification improved compared to that in the 7th, as the survival rate of T4 decreased (T2, 31.2%; T3, 13.9%; T4, 15.1%; T1- T2, p=0.260; T2-T3, p=0.001; T3-T4, p=0.996). Both editions showed significant survival differences between each N category, except between N1 and N2 (p=0.063) in 7th edition. Differences of point estimates between the 8th and 7th T and N classification and overall stages were +0.028, +0.006, and +0.039, respectively (T, p=0.005; N, p=0.115; overall stage, p=0.005). In multivariable analysis, posthepatectomy liver failure, T category, N category, distant metastasis, histologic differentiation, intraoperative transfusion, and resection margin status were associated with OS. Conclusion The prognostic predictability of 8th AJCC staging for PHCC improved slightly, with statistical significance, compared to the 7th edition, but its overall performance is still unsatisfactory.
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참고문헌 (30)
참고문헌 신청
Ebata T / 2009 / The concept of perihilar cholangiocarcinoma is valid / Br J Surg 96:926~934
Ebata T / 2014 / Proposal to modify the International Union Against Cancer staging system for perihilar cholangiocarcinomas / Br J Surg 101:79~88
Chun YS / 2018 / 8th edition of the AJCC cancer staging manual : pancreas and hepatobiliary cancers / Ann Surg Oncol 25:845~847
Steyerberg EW / 2010 / Assessing the performance of prediction models : a framework for traditional and novel measures / Epidemiology 21:128~138
Ebata T / 2003 / Hepatectomy with portal vein resection for hilar cholangiocarcinoma : audit of 52 consecutive cases / Ann Surg 238:720~727
Ebata T / 2014 / Proposal to modify the International Union Against Cancer staging system for perihilar cholangiocarcinomas / Br J Surg 101:79~88
Chun YS / 2018 / 8th edition of the AJCC cancer staging manual : pancreas and hepatobiliary cancers / Ann Surg Oncol 25:845~847
Steyerberg EW / 2010 / Assessing the performance of prediction models : a framework for traditional and novel measures / Epidemiology 21:128~138
Ebata T / 2003 / Hepatectomy with portal vein resection for hilar cholangiocarcinoma : audit of 52 consecutive cases / Ann Surg 238:720~727
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