The prognostic value of the lymph node ratio in patients with distal cholangiocarcinoma after curative intended surgery: A single-center retrospective study

Chaeyung Oh; Hee Joon Kim; Sang Hwa Song; Eun Kyu Park; Young Hoe Hur; Yang Seok Koh; Chol Kyoon Cho

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저자정보: Chaeyung Oh (Chonnam National University Medical School) Hee Joon Kim (Chonnam National University Medical School) Sang Hwa Song (Chonnam National University Medical School) Eun Kyu Park (Chonnam National University Medical School) Young Hoe Hur (Chonnam National University Medical School) Yang Seok Koh (Chonnam National University Medical School) Chol Kyoon Cho (Chonnam National University Medical School)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제26권 제2호

발행연도: 2022.5

수록면: 168 - 177 (10page)

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Backgrounds/Aims: The goal of the present study was to evaluate the prognostic value of lymph node ratio (LNR) in distal cholangiocarcinoma (DCC) after curative intended surgery.
Methods: Clinicopathological data of 162 DCC patients who underwent radical intended surgery between 2012 and 2020 were analyzed retrospectively. Prognostic factors related to overall survival (OS) and disease-free survival (DFS) were evaluated.
Results: Median OS time and DFS time were 41 and 29 months, and 5-year OS rate and DFS rate were 44.7% and 38.1%, respectively. In the univariate analysis, significant prognostic factors for OS were histologic differentiation, American Joint Committee on Cancer (AJCC) stage, positive lymph node count, LNR, R1 resection, and perineural invasion. Preoperative carcinoembryonic antigen, carbohydrate antigen 19-9, infiltrative type, histologic differentiation, AJCC stage, positive lymph node count, LNR, R1 resection, perineural invasion, and lymph-vascular invasion were significant prognostic factors for DFS in the univariate analysis. In the multivariate analysis, histologic differentiation, R1 resection, and LNR were the independent prognostic factors for both OS and DFS. The LNR ≥ 0.2 group had a significantly poor prognosis in terms of OS (hazard ratio, 3.915; p = 0.002) and DFS (hazard ratio, 5.840; p < 0.001).
Conclusions: LNR has significant value as a prognostic factor of DCC related to OS and DFS. LNR has the potential to be used as a modified staging system with furthermore studies.

#Cholangiocarcinoma #Pancreaticoduodenectomy #Lymph node ratio #Survival

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