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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제6호
- 발행연도
- 2019.1
- 수록면
- 501 - 508 (8page)
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초록· 키워드
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Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4+/CD8+ and the secretion of interleukin (IL)-2 and interferon-γ, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2 . The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.
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참고문헌 (29)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Sherman M / 2010 / Hepatocellular carcinoma : epidemiology, surveillance, and diagnosis / Semin Liver Dis 30:3~16
Nabavi SF / 2015 / The cellular protective effects of rosmarinic acid : from bench to bedside / Curr Neurovasc Res 12:98~105
Rocha J / 2015 / Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation / Basic Clin Pharmacol Toxicol 116:398~413
Karthikkumar V / 2015 / Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats / J Basic Clin Physiol Pharmacol 26:185~200
Sherman M / 2010 / Hepatocellular carcinoma : epidemiology, surveillance, and diagnosis / Semin Liver Dis 30:3~16
Nabavi SF / 2015 / The cellular protective effects of rosmarinic acid : from bench to bedside / Curr Neurovasc Res 12:98~105
Rocha J / 2015 / Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation / Basic Clin Pharmacol Toxicol 116:398~413
Karthikkumar V / 2015 / Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats / J Basic Clin Physiol Pharmacol 26:185~200
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