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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제3호
- 발행연도
- 2020.1
- 수록면
- 203 - 212 (10page)
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Promyelocytic leukemia (PML) gene, through alternative splicing of its Cterminal region, generates several PML isoforms that interact with specific partners and perform distinct functions. The PML protein is a tumor suppressor that plays an important role by interacting with various proteins. Herein, we investigated the effect of the PML isoforms on oncostatin M (OSM)-induced signal transducer and activator of transcription-3 (STAT-3) transcriptional activity. PML influenced OSMinduced STAT-3 activity in a cell type-specific manner, which was dependent on the p53 status of the cells but regardless of PML isoform. Interestingly, overexpression of PML exerted opposite effects on OSM-induced STAT-3 activity in p53 wild-type and mutant cells. Specifically, overexpression of PML in the cell lines bearing wild-type p53 (NIH3T3 and U87-MG cells) decreased OSM-induced STAT-3 transcriptional activity, whereas overexpression of PML increased OSM-induced STAT-3 transcriptional activity in mutant p53-bearing cell lines (HEK293T and U251-MG cells). When wild-type p53 cells were co-transfected with PML-IV and R273H-p53 mutant, OSM-mediated STAT-3 transcriptional activity was significantly enhanced, compared to that of cells which were transfected with PML-IV alone; however, when cells bearing mutant p53 were co-transfected with PML-IV and wild-type p53, OSM-induced STAT-3 transcriptional activity was significantly decreased, compared to that of transfected cells with PML-IV alone. In conclusion, PML acts together with wild-type or mutant p53 and influences OSM-mediated STAT-3 activity in a negative or positive manner, resulting in the aberrant activation of STAT-3 in cancer cells bearing mutant p53 probably might occur through the interaction of mutant p53 with PML.
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참고문헌 (33)
참고문헌 신청
Jensen K / 2001 / PML protein isoforms and the RBCC/TRIM motif / Oncogene 20:7223~7233
Salomoni P / 2008 / New insights into the role of PML in tumour suppression / Cell Res 18:622~640
Nisole S / 2013 / Differential roles of PML isoforms / Front Oncol 3:125
Imani-Saber Z / 2014 / Promyelocytic leukemia gene functions and roles in tumorigenesis / Asian Pac J Cancer Prev 15:8021~8028
Bernardi R / 2007 / Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies / Nat Rev Mol Cell Biol 8:1006~1016
Salomoni P / 2008 / New insights into the role of PML in tumour suppression / Cell Res 18:622~640
Nisole S / 2013 / Differential roles of PML isoforms / Front Oncol 3:125
Imani-Saber Z / 2014 / Promyelocytic leukemia gene functions and roles in tumorigenesis / Asian Pac J Cancer Prev 15:8021~8028
Bernardi R / 2007 / Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies / Nat Rev Mol Cell Biol 8:1006~1016
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