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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 548 - 552 (5page)
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초록· 키워드
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Progressive multifocal leukoencephalopathy (PML) is a devastating neurological disease observed nearly exclusively in immunocompromised patients. Recently, the introduction of monoclonal antibodies significantly inhibiting the immune system such as rituximab has led to an increase in PML cases. Although rituximab-based immunochemotherapy remains the standard of treatment for chronic lymphocytic leukemia (CLL), the importance of Bruton’s tyrosine kinase inhibitors such as ibrutinib is steadily increasing. However, long-term experiences regarding possible side effects of these new substances are rare. Here, we report the development of eventually fatal PML possibly associated with ibrutinib therapy for CLL after multiple prior treatment lines, including rituximab. To the best of our knowledge, this is the first study to report such findings. Since the last course of rituximab was applied over 3 years ago, it is conceivable that the strong B cell inhibition by ibrutinib led to PML. With increased awareness of this potential side effect, further clinical studies are certainly warranted to evaluate this possible association.
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참고문헌 (15)
참고문헌 신청
Astrom KE / 1958 / Progressive multifocal leuko-encephalopathy : a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin's disease / Brain 81 : 93 ~ 1
Bloomgren G / 2012 / Risk of natalizumab-associated progressive multifocal leukoencephalopathy / N Engl J Med 366 : 1870 ~ 1880
Carson KR / 2009 / Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients : a report of 57 cases from the Research on Adverse Drug Events
Clifford DB / 2013 / A study of mefloquine treatment for progressive multifocal leukoencephalopathy : results and exploration of predictors of PML outcomes / J Neurovirol 19
Epperla N / 2014 / Mirtazapine and mefloquine therapy for non-AIDS-related progressive multifocal leukoencephalopathy / WMJ 113 : 242 ~ 245
Bloomgren G / 2012 / Risk of natalizumab-associated progressive multifocal leukoencephalopathy / N Engl J Med 366 : 1870 ~ 1880
Carson KR / 2009 / Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients : a report of 57 cases from the Research on Adverse Drug Events
Clifford DB / 2013 / A study of mefloquine treatment for progressive multifocal leukoencephalopathy : results and exploration of predictors of PML outcomes / J Neurovirol 19
Epperla N / 2014 / Mirtazapine and mefloquine therapy for non-AIDS-related progressive multifocal leukoencephalopathy / WMJ 113 : 242 ~ 245
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