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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 48 - 56 (9page)
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Background: Anti-carbohydrate antibody responses, including those of anti-blood group ABO antibodies, are yet to be thoroughly studied in humans. Because anti-ABO antibody-mediated rejection is a key hurdle in ABO-incompatible transplantation, it is important to understand the cellular mechanism of anti-ABO responses. We aimed to identify the main human B cell subsets that produce anti-ABO antibodies by analyzing the correlation between B cell subsets and anti-ABO antibody titers. Methods: Blood group A-binding B cells were analyzed in peritoneal fluid and peripheral blood samples from 43 patients undergoing peritoneal dialysis and 18 healthy volunteers with blood group B or O. The correlation between each blood group A-specific B cell subset and anti-A antibody titer was then analyzed using Pearson’s correlation analysis. Results: Blood group A-binding B cells were enriched in CD27+CD43+CD1c− B1, CD5+ B1, CD11b+ B1, and CD27+CD43+CD1c+ marginal zone-B1 cells in peripheral blood. Blood group A-specific B1 cells (P=0.029 and R=0.356 for IgM; P=0.049 and R=0.325 for IgG) and marginal zone-B1 cells (P=0.011 and R=0.410 for IgM) were positively correlated with anti-A antibody titer. Further analysis of peritoneal B cells confirmed B1 cell enrichment in the peritoneal cavity but showed no difference in blood group A-specific B1 cell enrichment between the peritoneal cavity and peripheral blood. Conclusions: Human B1 cells are the key blood group A-specific B cells that have a moderate correlation with anti-A antibody titer and therefore constitute a potential therapeutic target for successful ABO-incompatible transplantation.
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참고문헌 (20)
참고문헌 신청
Morath C / 2017 / ABO-incompatible kidney transplantation / Front Immunol 8:234
Okumi M / 2016 / ABO-incompatible living kidney transplants : evolution of outcomes and immunosuppressive management / Am J Transplant 16:886~896
Segev DL / 2005 / Characterization of waiting times in a simulation of kidney paired donation / Am J Transplant 5:2448~2455
Mond JJ / 1995 / T cell-independent antigens type 2 / Annu Rev Immunol 13:655~692
Tazawa H / 2013 / Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates / Blood 122:2582~2590
Okumi M / 2016 / ABO-incompatible living kidney transplants : evolution of outcomes and immunosuppressive management / Am J Transplant 16:886~896
Segev DL / 2005 / Characterization of waiting times in a simulation of kidney paired donation / Am J Transplant 5:2448~2455
Mond JJ / 1995 / T cell-independent antigens type 2 / Annu Rev Immunol 13:655~692
Tazawa H / 2013 / Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates / Blood 122:2582~2590
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