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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 30 - 39 (10page)
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Background: This study examined the effects of gabexate mesilate on spinal nerve ligation (SNL)-induced neuropathic pain. To confirm the involvement of gabexate mesilate on neuroinflammation, we focused on the activation of nuclear factor-κB (NF-κB) and consequent the expression of proinflammatory cytokines and inducible nitric oxide synthase (iNOS). Methods: Male Sprague-Dawley rats were used for the study. After randomization into three groups: the sham-operation group, vehicle-treated group (administered normal saline as a control), and the gabexate group (administered gabexate mesilate 20 mg/kg), SNL was performed. At the 3rd day, mechanical allodynia was confirmed using von Frey filaments, and drugs were administered intraperitoneally daily according to the group. The paw withdrawal threshold (PWT) was examined on the 3rd, 7th, and 14th day. The expressions of p65 subunit of NF-κB, interleukin (IL)-1, IL-6, tumor necrosis factor-α, and iNOS were evaluated on the 7th and 14th day following SNL. Results: The PWT was significantly higher in the gabexate group compared with the vehicle-treated group (P < 0.05). The expressions of p65, proinflammatory cytokines, and iNOS significantly decreased in the gabexate group compared with the vehicle-treated group (P < 0.05) on the 7th day. On the 14th day, the expressions of p65 and iNOS showed lower levels, but those of the proinflammatory cytokines showed no significant differences. Conclusions: Gabexate mesilate increased PWT after SNL and attenuate the progress of mechanical allodynia. These results seem to be involved with the antiinflammatory effect of gabexate mesilate via inhibition of NF-κB, proinflammatory cytokines, and nitric oxide.
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참고문헌 (47)
참고문헌 신청
Gao J / 2018 / Pro-resolving mediator maresin 1 ameliorates pain hypersensitivity in a rat spinal nerve ligation model of neuropathic pain / J Pain Res 11:1511~1519
Oh SH / 2015 / Urinary trypsin inhibitor attenuates the development of neuropathic pain following spinal nerve ligation / Neurosci Lett 590:150~155
Guindon J / 2008 / Cannabinoid CB2 receptors : a therapeutic target for the treatment of inflammatory and neuropathic pain / Br J Pharmacol 153:319~334
Sacerdote P / 2013 / Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain / J Neuroimmune Pharmacol 8:202~211
Austin PJ / 2010 / The neuro-immune balance in neuropathic pain : involvement of inflammatory immune cells, immune-like glial cells and cytokines / J Neuroimmunol 229:26~50
Oh SH / 2015 / Urinary trypsin inhibitor attenuates the development of neuropathic pain following spinal nerve ligation / Neurosci Lett 590:150~155
Guindon J / 2008 / Cannabinoid CB2 receptors : a therapeutic target for the treatment of inflammatory and neuropathic pain / Br J Pharmacol 153:319~334
Sacerdote P / 2013 / Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain / J Neuroimmune Pharmacol 8:202~211
Austin PJ / 2010 / The neuro-immune balance in neuropathic pain : involvement of inflammatory immune cells, immune-like glial cells and cytokines / J Neuroimmunol 229:26~50
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