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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 248 - 257 (10page)
이용수
초록· 키워드
오류제보하기
Apios americana Medik tubers are medicinal foods with anti-cancer and anti-inflammatory activities. However, mechanisms of immunostimulatory action of the Apios tuber extract (ATE) on macrophages have not been elucidated. In the present study, we investigated whether ATE could modulate immune responses, such as production of nitric oxide (NO), proinflammatory cytokines, and transcription factors, in RAW264.7 macrophage cells. ATE significantly increased the production of NO and proinflammatory cytokines such as interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), and induced the mRNA and protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and proinflammatory cytokines in a dose-dependent manner. Furthermore, Western blot analysis revealed that ATE activated the transcription factor Nuclear Factor-κB and mitogen-activated protein kinases signaling cascades, including extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 kinase. In addition, we found that ATE induced the activation of macrophages through upregulation of toll-like receptor 4 (TLR4) and TLR2. Taken together, these findings indicate that ATE possesses a potential as a functional food with immunostimulatory activity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Hamsa TP / 2011 / Evaluation of the anti-inflammatory and anti-tumor effect of Ipomoea obscura (L. and its mode of action through the inhibition of proinflammatory cytokines, nitric oxide and COX-2 / Inflammation 34 : 171 ~ 183
[학술지(정기간행물)] - Zhang L / 2007 / Proteomic analysis of macrophages : a potential way to identify novel proteins associated with activation of macrophages for tumor cell killing / Cell Mol Immunol 4 : 359 ~ 367
[학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
[학술지(정기간행물)] - Aderem A / 2000 / Toll-like receptors in the induction of the innate immune response / Nature 406 : 782 ~ 787
[학술지(정기간행물)] - Shi Z / 2011 / A novel Toll-like receptor that recognizes vesicular stomatitis virus / J Biol Chem 286 : 4517 ~ 4524
[학술지(정기간행물)] - Zhang L / 2007 / Proteomic analysis of macrophages : a potential way to identify novel proteins associated with activation of macrophages for tumor cell killing / Cell Mol Immunol 4 : 359 ~ 367
[학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
[학술지(정기간행물)] - Aderem A / 2000 / Toll-like receptors in the induction of the innate immune response / Nature 406 : 782 ~ 787
[학술지(정기간행물)] - Shi Z / 2011 / A novel Toll-like receptor that recognizes vesicular stomatitis virus / J Biol Chem 286 : 4517 ~ 4524
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UCI(KEPA) : I410-ECN-0101-2017-475-001976816