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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 662 - 668 (7page)
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The purpose of this study was to investigate effect of methanolic extracts of 10 kinds of wild vegetables cultivated in Gangwon province on antioxidant activity, acetylcholinesterase, and β-secretase inhibitory activities. Results showed that among the wild vegetables, Aralia elata(Miq.) Seem shoot extract exhibited the highest total phenol content (84.65±1.08 mg GAE/g) and total flavonoids content (70.77±0.55 mg RE/g), respectively. The antioxidant activity of wild vegetables extracts was measured by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. Aralia elata(Miq.) Seem shoot extracts had the highest DPPH and ABTS scavenging activity (90.16%, 40.18% at 2 mg/mL). As a result, Aralia elata(Miq.) Seem shoot extract was the most effective in terms of acetylcholinesterase inhibitory activity (35.94% at 1 mg/mL). In the β-secretase activity assay, all 10 kinds wild vegetables extracts showed low inhibitory activity, and Aralia elata(Miq.) Seem shoot extract had highest inhibitory activity among the 10 wild vegetables extracts was 14.99%. Taken together, these results showed that Aralia elata(Miq.) Seem shoot extract has potential cognition improvement impact, suggesting that it may provide an effective strategy for improving cognition. Key words: wild vegetables extracts, antioxidant activity, cognition improvement effect, acetylcholinesterase, β-secretase
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참고문헌 (30)
참고문헌 신청
차재영 / 2009 / 두릅 순 및 잎 추출물의 항산화 효과 / 생명과학회지 19(5):652~658
Coyle JT / 1983 / Alzheimer's disease : a disorder of cortical cholinergic innervation / Science 219:1184~1190
Milind Parle / 2006 / Comparative Brain Cholinesterase-Inhibiting Activity of Glycyrrhiza glabra, Myristica fragrans, Ascorbic Acid, and Metrifonate in Mice / Journal of Medicinal Food 9(2):281~283
Duval B / 2001 / The stimulation of phenolics and antioxidant activity in pea(Pisum sativum)elicited by genetically transformed anise root extract / J Food Biochem 25:361~377
Ellman GL / 1961 / A new and rapid colorimetric determination of acetylcholinesterase activity / Biochem Pharmacol 7:88~95
Coyle JT / 1983 / Alzheimer's disease : a disorder of cortical cholinergic innervation / Science 219:1184~1190
Milind Parle / 2006 / Comparative Brain Cholinesterase-Inhibiting Activity of Glycyrrhiza glabra, Myristica fragrans, Ascorbic Acid, and Metrifonate in Mice / Journal of Medicinal Food 9(2):281~283
Duval B / 2001 / The stimulation of phenolics and antioxidant activity in pea(Pisum sativum)elicited by genetically transformed anise root extract / J Food Biochem 25:361~377
Ellman GL / 1961 / A new and rapid colorimetric determination of acetylcholinesterase activity / Biochem Pharmacol 7:88~95
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