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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제3호
- 발행연도
- 2020.1
- 수록면
- 271 - 293 (23page)
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Background Known as the main site of ATP production and intrinsic apoptosis regulator, mitochondria play vital roles in physiological functions and pathological progression. Evidences have shown that mitochondrial dysfunction correlated with a variety of diseases, especially with cancer. Mitochondria are emerged as an attractive target for diseases treatment. Area covered This review introduces efficient mitochondrial targeting strategies, and summarizes application of multiple drug delivery systems targeted to mitochondria for antitumor treatment, including anti-drug resistance, anti-metastasis and immunotherapy. Furthermore, we discuss the application and perspectives of mitochondrial targeting in treatment of other mitochondrial-related diseases. Expert opinion A number of chemotherapeutics exert their efficacy in specific sub-organelles. Targeting drugs to one certain organelle would exhibit their maximum therapeutic effects. The mitochondria in tumor cells are closely related to the development of tumor. Also, the main cause of clinical failure in antitumor treatment, including multidrug resistance (MDR) and metastasis, are associated with mitochondrial dysfunction. In addition, mitochondria disorders also lead to some other diseases. Therefore, constructing mitochondrial targeted drug delivery systems to regulate mitochondrial functions is necessarily desired.
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참고문헌 (153)
참고문헌 신청
Abe J / 2016 / Validation of a strategy for cancer therapy : delivering aminoglycoside drugs to mitochondria in hela cells / J Pharm Sci 105(2):734~740
Ajith TA / 2014 / Mitochondria-targeted agents : future perspectives of mitochondrial pharmaceutics in cardiovascular diseases / World J Cardiol 6(10):1091
Alsaab HO / 2017 / PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy : mechanism, combinations, and clinical outcome / Front Pharmacol 8:561
Banerjee D / 2011 / Nanotechnology-mediated targeting of tumor angiogenesis / Vasc Cell 3(1):3
Battogtokh G / 2018 / Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment / Front Pharmacol
Ajith TA / 2014 / Mitochondria-targeted agents : future perspectives of mitochondrial pharmaceutics in cardiovascular diseases / World J Cardiol 6(10):1091
Alsaab HO / 2017 / PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy : mechanism, combinations, and clinical outcome / Front Pharmacol 8:561
Banerjee D / 2011 / Nanotechnology-mediated targeting of tumor angiogenesis / Vasc Cell 3(1):3
Battogtokh G / 2018 / Mitochondrial-targeting anticancer agent conjugates and nanocarrier systems for cancer treatment / Front Pharmacol
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