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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 395 - 405 (11page)
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초록· 키워드
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Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.
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등록된 정보가 없습니다.
참고문헌 (76)
참고문헌 신청
Zhou B / 2018 / Mitochondrial dysfunction in pathophysiology of heart failure / J Clin Invest 128:3716~3726
Pickles S / 2018 / Mitophagy and quality control mechanisms in mitochondrial maintenance / Curr Biol 28:R170~85
Smyrnias I / 2019 / Cardioprotective effect of the mitochondrial unfolded protein response during chronic pressure overload / J Am Coll Cardiol 73:1795~1806
Campos JC / 2016 / Mitochondrial quality control in cardiac diseases / Front Physiol 7:479
Guaragnella N / 2018 / Mitochondria-cytosol-nucleus crosstalk : learning from Saccharomyces cerevisiae / FEMS Yeast Res 18:foy088
Pickles S / 2018 / Mitophagy and quality control mechanisms in mitochondrial maintenance / Curr Biol 28:R170~85
Smyrnias I / 2019 / Cardioprotective effect of the mitochondrial unfolded protein response during chronic pressure overload / J Am Coll Cardiol 73:1795~1806
Campos JC / 2016 / Mitochondrial quality control in cardiac diseases / Front Physiol 7:479
Guaragnella N / 2018 / Mitochondria-cytosol-nucleus crosstalk : learning from Saccharomyces cerevisiae / FEMS Yeast Res 18:foy088
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