Efficacy of Mastocheck for Screening of Early Breast Cancer: Comparison with Screening Mammography

Yumi Kim; Hyeong-Gon Moon; Han-Byoel Lee; Woo Kyung Moon; Nariya Cho; Jung-Min Chang; Wonshik Han; Dong-Young Noh

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자료유형: 학술저널

저자정보: Yumi Kim Hyeong-Gon Moon Han-Byoel Lee Woo Kyung Moon Nariya Cho Jung-Min Chang Wonshik Han Dong-Young Noh

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제7권 제2호

발행연도: 2019.1

수록면: 59 - 64 (6page)

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연구주제

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연구배경

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연구방법

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Purpose: This study was designed to verify the effectiveness of Mastocheck, a new diagnostic tool developed with proteomics techniques using plasma proteins. In addition, checked the current state of mammography used for breast cancer screening. Methods: A total of 305 cases were analyzed (normal 122, breast cancer 183) and used for validation after Mastocheck development. First, screening mammograms of normal patients and pre-diagnosis mammography of cancer patients were reviewed retrospectively. The results were compared with Mastocheck, a newly developed blood test. Imaging tests were blinded and analyzed by dividing the readings of breast specialists and non-breast specialists among radiologists. We confirmed how much better the results would be if only the mammography was used and if both tests were used together. Results: The sensitivity, specificity, and accuracy of mammography alone, reviewed by non-breast specialists among radiologists, were 63.0%, 85.7%, and 71.3%, respectively. In dense breasts, the values were 59.2%, 84.8% and 69.0%, which were too low to be considered interpretable. The sensitivity, specificity and accuracy of the test was 93.9%, 75.2%, and 87.1% when using mammography and Mastocheck together. From these results, an improvement in sensitivity of about 30% and an improvement in accuracy of about 15% or more in concomitant use than mammography alone can be seen. Conclusion: Mastocheck can be widely used for screening breast cancer, especially in dense breasts, patients with low accuracy in mammography, and patients with mammography side effects. In addition, it has the advantage of increasing the diagnosis rate when used with mammography, the current screening method of choice.

참고문헌 (21)

참고문헌 신청

Korean Breast Cancer Society / 2018 / Breast Cancer Facts & Figures 2018

Stewart BW / 2014 / World cancer report 2014

정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316

Kim SH / 2000 / Analysis and comparison of breast density according to age on mammogram between Korean and western women / J Korean Radiol Soc 42:1009~1014

Hasegawa S / 2003 / Breast cancer imaging by mammography: effects of age and breast composition / J Jpn Assoc Breast Cancer Screen 120:101~107

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소속기관 Department of Surgery, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.