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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 626 - 632 (7page)
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Purpose: To compare the effect of apixaban and low molecular weight heparin (LMWH) in the prevention and treatment of deepvenous thrombosis (DVT) after total knee arthroplasty in older adult patients. Materials and Methods: A total of 220 patients (average age of 67.8±6.4 years) undergoing total knee arthroplasty were randomlyselected as research subjects and were divided into apixaban and LMWH groups (110 in each group). Results: The incidence of DVT was lower in the apixaban group than in the LMWH group (5.5% vs. 20.0%, p=0.001). Activatedpartial thromboplastin times (35.2±3.6 sec vs. 33.7±2.2 sec, p=0.010; 37.8±4.6 sec vs. 34.1±3.2 sec, p<0.001; 39.6±5.1 sec vs. 35.7±3.0sec, p=0.032) and prothrombin times (14.0±1.0 sec vs. 12.8±0.9 sec, p<0.001; 14.5±1.2 sec vs. 13.0±1.1 sec, p<0.001; 15.3±1.4 sec vs. 13.2±1.3 sec, p=0.009) in the apixaban group at 1 week after surgery, 3 weeks after surgery, and the end of treatment were higherthan those in the LMWH group. Platelet and fibrinogen levels in the apixaban group were lower than those of the LMWH group. Also, capillary plasma viscosity and erythrocyte aggregation in the apixaban group at 1 week after surgery, 3 weeks after surgery,and the end of treatment were lower than those in the LMWH group. Conclusion: Apixaban, which elicits fewer adverse reactions and is safer than LMWH, exhibited better effects in the preventionand treatment of DVT after total knee arthroplasty in older adults.
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참고문헌 (22)
참고문헌 신청
Bonutti PM / 2017 / Novel venous thromboembolic disease (VTED) prophylaxis for total knee arthroplasty-aspirin and fish oil / Ann Transl Med 5(Suppl 3):S30
Zhou LY / 2018 / Effects of inhalation anesthesia vs. total intravenous anesthesia (TIVA) vs. spinal-epidural anesthesia on deep vein thrombosis after total knee arthroplasty / Med Sci Monit 24:67~75
Falck-Ytter Y / 2012 / Prevention of VTE in orthopedic surgery patients. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines / Chest 141(2 Suppl):e278S~e325S
Wakabayashi H / 2017 / The risk factor of preoperative deep vein thrombosis in patients undergoing total knee arthroplasty / J Orthop Sci 22:698~702
Zou Y / 2014 / Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty / Blood Coagul Fibrinolysis 25:660~664
Zhou LY / 2018 / Effects of inhalation anesthesia vs. total intravenous anesthesia (TIVA) vs. spinal-epidural anesthesia on deep vein thrombosis after total knee arthroplasty / Med Sci Monit 24:67~75
Falck-Ytter Y / 2012 / Prevention of VTE in orthopedic surgery patients. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines / Chest 141(2 Suppl):e278S~e325S
Wakabayashi H / 2017 / The risk factor of preoperative deep vein thrombosis in patients undergoing total knee arthroplasty / J Orthop Sci 22:698~702
Zou Y / 2014 / Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty / Blood Coagul Fibrinolysis 25:660~664
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