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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 145 - 153 (9page)
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Purpose: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneousascitic infection (SAI) in patients with acute decompensated cirrhosis. Materials and Methods: We retrospectively analyzed 432 acute decompensated cirrhotic patients with culture-positive SAI from11 teaching hospitals in China (January 2012 to May 2018). A Cox proportional hazards model analysis was conducted to identifyindependent predictors of 28-day mortality. Results: A total of 455 strains were isolated from 432 ascitic culture samples. Gram-negative bacteria (GNB), gram-positive bacteria(GPB), and fungi caused 52.3, 45.5, and 2.2% of all SAI episodes, respectively. Episodes were classified as nosocomial (41.2%), healthcare-related (34.7%), and community-acquired (24.1%). Escherichia coli (13.4%) and Klebsiella pneumoniae (2.4%) were extendedspectrumβ-lactamase producing isolates. The prevalence of methicillin-resistant Staphylococcus aureus was 1.1%. Ceftazidime,cefepime, aztreonam, and amikacin were recommended as first-line antibiotics agents for non-MDR GNB infections; piperacillin/tazobactam and carbapenems for MDR GNB in community-acquired and healthcare-related or nosocomial infections, respectively;and vancomycin or linezolid for GPB infections, regardless of drug-resistance status. Multivariate analysis revealed days ofhospital stay before SAI, upper gastrointestinal bleeding, white blood cell count, alanine aminotransferase, serum creatinine concentration,total bilirubin, and international normalized ratio as key independent predictors of 28-day mortality. Conclusion: MDR pathogens and antibiotic strategies were identified in patients with acute decompensated cirrhosis with culture-positive SAI, which may help optimize therapy and improve clinical outcomes.
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참고문헌 (29)
참고문헌 신청
Schwabl P / 2015 / Risk factors for development of spontaneous bacterial peritonitis and subsequent mortality in cirrhotic patients with ascites / Liver Int 35:2121~2128
Garcia-Tsao G / 2004 / Bacterial infections in cirrhosis / Can J Gastroenterol 18:405~406
Leber B / 2012 / Infectious complications of acute and chronic liver disease / Semin Respir Crit Care Med 33:80~95
Moreau R / 2013 / Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis / Gastroenterology 144:1426~1437
Kaymakoglu S / 1997 / Spontaneous ascitic infection in different cirrhotic groups : prevalence, risk factors and the efficacy of cefotaxime therapy / Eur J Gastroenterol Hepatol 9:71~76
Garcia-Tsao G / 2004 / Bacterial infections in cirrhosis / Can J Gastroenterol 18:405~406
Leber B / 2012 / Infectious complications of acute and chronic liver disease / Semin Respir Crit Care Med 33:80~95
Moreau R / 2013 / Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis / Gastroenterology 144:1426~1437
Kaymakoglu S / 1997 / Spontaneous ascitic infection in different cirrhotic groups : prevalence, risk factors and the efficacy of cefotaxime therapy / Eur J Gastroenterol Hepatol 9:71~76
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