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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 120 - 128 (9page)
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초록· 키워드
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Purpose: Stroke prevention in patients with atrial fibrillation (AF) is influenced by many factors. Using a contemporary registry,we evaluated variables associated with the use of warfarin or direct oral anticoagulants (OACs). Materials and Methods: In the prospective multicenter CODE-AF registry, 10529 patients with AF were evaluated. Multivariateanalyses were performed to identify variables associated with the use of anticoagulants. Results: The mean age of the patients was 66.9±14.4 years, and 64.9% were men. The mean CHA2DS2-VASc and HAS-BLED scoreswere 2.6±1.7 and 1.8±1.1, respectively. In patients with high stroke risk (CHA2DS2-VASc ≥2), OACs were used in 83.2%, including directOAC in 68.8%. The most important factors for non-OAC treatment were end-stage renal disease [odds ratio (OR) 0.27; 95%confidence interval (CI): 0.19–0.40], myocardial infarct (OR 0.53; 95% CI: 0.40–0.72), and major bleeding (OR 0.57; 95% CI: 0.39–0.84). Female sex (OR 1.40; 95% CI: 1.21–1.61), cancer (OR 1.78; 95% CI: 1.38–2.29), and smoking (OR 1.60; 95% CI: 1.15–2.24) werefactors favoring direct OAC use over warfarin. Among patients receiving OACs, the rate of combined antiplatelet agents was 7.8%. However, 73.6% of patients did not have any indication for a combination of antiplatelet agents. Conclusion: Renal disease and history of valvular heart disease were associated with warfarin use, while cancer and smoking statuswere associated with direct OAC use in high stroke risk patients. The combination of antiplatelet agents with OAC was prescribedin 73.6% of patients without definite indications recommended by guidelines.
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참고문헌 (32)
참고문헌 신청
이한철 / 2017 / The Trends of Atrial Fibrillation-Related Hospital Visit and Cost, Treatment Pattern and Mortality in Korea: 10-Year Nationwide Sample Cohort Data / Korean Circulation Journal 47(1):56~64
Kim TH / 2017 / CHA2DS2-VASc score(congestive heart failure, hypertension, age ≥75 [doubled], diabetes mellitus, prior stroke or transient ischemic attack [doubled], vascular disease, age 65-74, female)for stroke in Asian patients with atrial fibrillation : a Korean nationwide sample cohort study / Stroke 48:1524~1530
Kim D / 2018 / 10-year nationwide trends of the incidence, prevalence, and adverse outcomes of non-valvular atrial fibrillation nationwide health insurance data covering the entire Korean population / Am Heart J 202:20~26
Kim D / 2018 / Increasing trends in hospital care burden of atrial fibrillation in Korea, 2006through 2015 / Heart 104:2010~2017
정보영 / 2018 / 2018 Korean Guideline of Atrial Fibrillation Management / Korean Circulation Journal 48(12):1033~1080
Kim TH / 2017 / CHA2DS2-VASc score(congestive heart failure, hypertension, age ≥75 [doubled], diabetes mellitus, prior stroke or transient ischemic attack [doubled], vascular disease, age 65-74, female)for stroke in Asian patients with atrial fibrillation : a Korean nationwide sample cohort study / Stroke 48:1524~1530
Kim D / 2018 / 10-year nationwide trends of the incidence, prevalence, and adverse outcomes of non-valvular atrial fibrillation nationwide health insurance data covering the entire Korean population / Am Heart J 202:20~26
Kim D / 2018 / Increasing trends in hospital care burden of atrial fibrillation in Korea, 2006through 2015 / Heart 104:2010~2017
정보영 / 2018 / 2018 Korean Guideline of Atrial Fibrillation Management / Korean Circulation Journal 48(12):1033~1080
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