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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 11 (11page)
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Objectives : The purpose of this study was to investigate the anti-inflammatory and anti-oxidative effects of Osung–tang(OST) extract. Methods : MTT assay was performed to confirm the survival rate of RAW 264.7 cells treated with OST extract(50-400㎍/㎖) and the production of NO from LPS-induced RAW 264.7 cells was confirmed. The mRNA expression of iNOS, COX-2, and NF-κB were measured by real-time PCR. The protein expression of iNOS, COX-2 and p-IκB were measured by western blot and the anti-oxidant activity of OST extract(50-400㎍/㎖) was investigated by measuring DPPH scavenging activity. Results : OST extract showed a cell survival rate of 90% or more at 50-400㎍/㎖. The NO production was inhibited in a dose-dependent manner in RAW 264.7 cells treated with LPS on OST treated group. mRNA expression levels of iNOS, COX-2 and NF-κB decreased in a concentration-dependent manner after treatment with OST(50-400㎍/㎖). Protein expression levels of iNOS, COX-2 and p-IκB decreased in a concentration-dependent manner after treatment with OST(50-400㎍/㎖). It was found that OST has a high free-radical scavenging ability. Conclusions : These results suggest that OST extract can be used as a treatment for various skin diseases by demonstrating its anti-inflammatory and anti-oxidant effects.
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참고문헌 (28)
참고문헌 신청
Jew SS / 2003 / Antiinflammatory Effects of Asiaticoside on Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 cell line / Official Journal of Korean Society of Toxicology 19(1):33~37
Medzhitov R / 2007 / Recognition of Microorganisms and Activation of the Immune Response / Nature 449(7164):819~826
Chen F / 2001 / New insights into the Role of Nuclear Factor-kappaB in Cell Growth Regulation / The American journal of pathology 159(2):387~397
Nathan CF / 1987 / Secretory Products of Macrophages / The Journal of Clinical Investigation 79(2):319~326
김대희 / 2009 / LPS로 활성화된 대식세포에서 黃連解毒湯 물추출물의 염증매개물질 억제효과 / 대한본초학회지 24(4):39~47
Medzhitov R / 2007 / Recognition of Microorganisms and Activation of the Immune Response / Nature 449(7164):819~826
Chen F / 2001 / New insights into the Role of Nuclear Factor-kappaB in Cell Growth Regulation / The American journal of pathology 159(2):387~397
Nathan CF / 1987 / Secretory Products of Macrophages / The Journal of Clinical Investigation 79(2):319~326
김대희 / 2009 / LPS로 활성화된 대식세포에서 黃連解毒湯 물추출물의 염증매개물질 억제효과 / 대한본초학회지 24(4):39~47
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