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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 204 - 212 (9page)
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초록· 키워드
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Purpose: This study aimed to investigate the prevalence of delayed thyroid dysfunction based on iodine disinfectant use and to analyze associated risk factors. Methods: A retrospective study was conducted on late preterm infants admitted to the neonatal intensive care unit between January 2010 and June 2018, who underwent neonatal thyroid screening (NTS) and ≥2 thyroid function tests (TFTs). NTS was performed 3 days after birth, with at least two TFTs 1 week and 2 to 4 weeks after birth. To distinguish between normal and dysfunctional thyroid levels, we reviewed TFT results at 2 to 4 weeks and examined possible risk factors for the development of thyroid dysfunction. Results: Of 295 late preterm infants, 262 were enrolled with a mean gestational age and birth weight of 34.8±0.7 weeks and 2,170±454 g, respectively. A total of 7.6% developed hyperthyrotropinemia at the age of 24.3±14.6 days (range, 12 to 69). The incidence of hyperthyrotropinemia during iodine use was approximately 12.6%, while that during discontinuation was 2.4% (P=0.002). Multivariate analysis revealed that small for gestational age (SGA), iodine disinfectant use, and abnormal NTS results were significant risk factors for delayed hyperthyrotropinemia (adjusted odds ratio [AOR]: 4.27, P=0.008; AOR: 8.24, P=0.003; and AOR: 7.80, P=0.002, respectively). Conclusion: Delayed hyperthyrotropinemia was prevalent in late preterm infants exposed to topical iodine and those identified as being SGA. Secondary TFTs should be considered 2 to 4 weeks after birth for this population at risk.
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참고문헌 (40)
참고문헌 신청
Blencowe H / 2012 / National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990for selected countries: a systematic analysis and implications / Lancet 379:2162~2172
Woythaler M. / 2019 / Neurodevelopmental outcomes of the late preterm infant / Semin Fetal Neonatal Med 24:54~59
Raju TN / 2006 / Optimizing care and outcome for late-preterm (near-term) infants: a summary of the workshop sponsored by the National Institute of Child Health and Human Development / Pediatrics 118:1207~1214
Kugelman A / 2013 / Late preterm infants: near term but still in a critical developmental time period / Pediatrics 132:741~751
McGowan JE / 2011 / Early childhood development of late-preterm infants: a systematic review / Pediatrics 127:1111~1124
Woythaler M. / 2019 / Neurodevelopmental outcomes of the late preterm infant / Semin Fetal Neonatal Med 24:54~59
Raju TN / 2006 / Optimizing care and outcome for late-preterm (near-term) infants: a summary of the workshop sponsored by the National Institute of Child Health and Human Development / Pediatrics 118:1207~1214
Kugelman A / 2013 / Late preterm infants: near term but still in a critical developmental time period / Pediatrics 132:741~751
McGowan JE / 2011 / Early childhood development of late-preterm infants: a systematic review / Pediatrics 127:1111~1124
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