지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 93 - 98 (6page)
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초록· 키워드
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Purpose: 5-Alpha reductase inhibitors (5ARI), inhibit the conversion of testosterone to dihydrotestosterone, which is essential in prostate hyperplasia, and decreases the prostate volume directly. On the other hand, 5ARI have a range of side effects, such as sexual dysfunction. After the discontinuation of 5ARI, prostate regrowth occurs rapidly until it reaches the baseline size. This study examined the effects of 5ARI when used intermittently.Materials and Methods: Between March 2009 and May 2017, patients who visited one physician’s outpatient clinic and were diagnosed with BPH underwent transrectal ultrasonography. The selected patients began to take 5ARI until the prostate size decreased at least 10% of the baseline (the first medication). After confirming adequate prostate shrinkage, the patients stopped medication until prostate regrowth reached 50% of the decreased size. After regrowth, they restarted medication for one year (second medication). The prostate size, serum prostate specific antigen (PSA) levels, international prostate symptom score (IPSS) scores, and maximum flow rate (Qmax) in uroflowmetry were collected after the first and second medication and compared using paired t-tests.Results: Sixty patients with a mean age of 65.1 years were included in the study. The prostate size and serum PSA level increased after the second medication compared to the first, and the prostate reduction and Qmax in uroflowmetry decreased significantly. On the other hand, the symptoms felt by the patients surveyed by the IPSS scores showed no significant difference.Conclusions: 5ARI appear to be less effective in reducing the prostate volume and improving uroflowmetry after discontinuation.
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참고문헌 (21)
참고문헌 신청
Boyle P / 2004 / 5-Alpha reductase inhibition provides superior benefits to alpha blockade by preventing AUR and BPH-related surgery / Eur Urol 45:620~626
Jacobsen SJ / 1997 / Natural history of prostatism : risk factors for acute urinary retention / J Urol 158:481~487
Oelke M / 2013 / Guidelines on the management of male lower urinary tract symptoms (LUTS), incl. benign prostatic obstruction (BPO) / European Association of Urology
Marks LS / 2006 / The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors : a review and clinical recommendations / J Urol 176:868~874
Seftel AD / 2013 / Coexisting lower urinary tract symptoms and erectile dysfunction : a systematic review of epidemiological data / Int J Clin Pract 67:32~45
Jacobsen SJ / 1997 / Natural history of prostatism : risk factors for acute urinary retention / J Urol 158:481~487
Oelke M / 2013 / Guidelines on the management of male lower urinary tract symptoms (LUTS), incl. benign prostatic obstruction (BPO) / European Association of Urology
Marks LS / 2006 / The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors : a review and clinical recommendations / J Urol 176:868~874
Seftel AD / 2013 / Coexisting lower urinary tract symptoms and erectile dysfunction : a systematic review of epidemiological data / Int J Clin Pract 67:32~45
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